Molecular epidemiology and HIV-1 variant evolution in Poland between 2015 and 2019

Autor: Anna Urbańska, Magdalena Witak-Jędra, Władysław Łojewski, Maria Jankowska, Maria Hlebowicz, Adam Witor, Monika Bociąga-Jasik, Błażej Rozpłochowski, Anita Olczak, Miłosz Parczewski, Martyna Biała, Aldona Kowalczuk-Kot, Anna Kalinowska-Nowak, Elżbieta Jabłonowska, Hubert Cieplucha, Kaja Scheibe, Karol Serwin
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
ISSN: 2045-2322
Popis: The occurrence of HIV-1 subtypes differs worldwide and within Europe, with non-B variants mainly found across different exposure groups. In this study, we investigated the distribution and temporal trends in HIV-1 subtype variability across Poland between 2015 and 2019. Sequences of the pol gene fragment from 2518 individuals were used for the analysis of subtype prevalence. Subtype B was dominant (n = 2163, 85.90%). The proportion of subtype B-infected individuals decreased significantly, from 89.3% in 2015 to 80.3% in 2019. This was related to the increasing number of subtype A infections. In 355 (14.10%) sequences, non-B variants were identified. In 65 (2.58%) samples, recombinant forms (RFs) were noted. Unique recombinant forms (URFs) were found in 30 (1.19%) sequences. Three A/B recombinant clusters were identified of which two were A6/B mosaic viruses not previously described. Non-B clades were significantly more common among females (n = 81, 22.8%, p = 0.001) and heterosexually infected individuals (n = 45, 32.4%, p = 0.0031). The predominance of subtype B is evident, but the variability of HIV-1 in Poland is notable. Almost half of RFs (n = 65, 2.58%) was comprised of URFs (n = 30, 1.19%); thus those forms were common in the analyzed population. Hence, molecular surveillance of identified variants ensures recognition of HIV-1 evolution in Poland.
Databáze: OpenAIRE
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