The relevance of EGFR overexpression for the prediction of the malignant transformation of oral leukoplakia
| Autor: | Moritz Bechtold, Eleftherios Vairaktaris, Emeka Nkenke, Abbas Agaimy, Jutta Ries, Patricia Gorecki, Friedrich Wilhelm Neukam |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Biology Malignant transformation Immunoenzyme Techniques stomatognathic system Internal medicine Biomarkers Tumor medicine Carcinoma Humans Retrospective Studies Leukoplakia Hyperplasia Oncogene Mouth Mucosa Case-control study Cancer General Medicine Middle Aged Prognosis medicine.disease Molecular medicine ErbB Receptors stomatognathic diseases Cell Transformation Neoplastic ROC Curve Dysplasia Case-Control Studies Carcinoma Squamous Cell Female Mouth Neoplasms Leukoplakia Oral Neoplasm Grading Precancerous Conditions Follow-Up Studies |
| Zdroj: | Oncology Reports. 30:1149-1156 |
| ISSN: | 1791-2431 1021-335X |
| Popis: | The present study evaluated the relevance of EGFR overexpression in prediction of malignant transformation of oral leukoplakia (OLP). The retrospective study comprised paraffin-embedded tissue samples of OLP that transformed into oral squamous cell carcinoma (OSCC) (n=53) and tissue samples of OLP that did not transform into OSCC (n=45) during a follow-up period of 5 years. EGFR overexpression was assessed immunohistochemically. A significantly different expression rate of EGFR was determined between transformed and non-transformed OLP (p=0.017). A statistically significant increase of EGFR expression for low dysplasia lesions in group I compared to group II was proven (D0, p=0.013; D1, p=0.049). By calculation of ROC curve and determination of highest Youden index the optimal threshold value [cut-off point (COP) = 44.96] for distinguishing the transformed from non-transformed lesions was estimated (critical expression rate of EGFR). Using the determined COP the correlation between high-risk lesions and the detection of increased expression rates were significant (p=0.001). In the future, the assessment of EGFR overexpression in OLP may allow identifying OLP lesions with an increased risk of malignant transformation that may have been regarded harmless when only the grade of dysplasia had been taken into account. |
| Databáze: | OpenAIRE |
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