Human schistosomiasis: Schistosoma mansoni antigen detection in renal glomeruli
| Autor: | Thales de Brito, S Hoshino-Shimizu, Adavio de Oliveira e Silva, Afonso R. Campos, Decio O. Penna, Luiz Caetano da Silva, Abaete L. Canto, Hermínia Yohko Kanamura |
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| Rok vydání: | 1976 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Kidney Glomerulus Schistosomiasis Antigen-Antibody Complex Immunoglobulin G Epitopes Antigen Antibody Specificity medicine Humans Antigens Child biology Public Health Environmental and Occupational Health Glomerulonephritis Schistosoma mansoni General Medicine medicine.disease biology.organism_classification Infectious Diseases Immunoglobulin M Immunology biology.protein Female Parasitology Antibody Immune complex disease |
| Zdroj: | Transactions of the Royal Society of Tropical Medicine and Hygiene. 70:492-496 |
| ISSN: | 0035-9203 |
| DOI: | 10.1016/0035-9203(76)90135-8 |
| Popis: | Twelve kidney, five biopsy and seven necropsy specimens, all from schistosomiasis mansoni patients were studied by light and immunoflurescent microscopy in an attempt to detect antigen in the glomerular walls. Deposits of IgM, IgG,I gA, IgE, complement C3 and fibrinogen were observered in most cases. Antigen was successfully detected in two cases(one biopsy and one necropsy specimen), both exhibiting proliferative glomerulonephritis. The only clinical manifestation was a slight proteinuria. IgG antibodies eluted from the sutopsy kidney homogenates showed specific binding mostly to Schistosoma mansoni gut, thus spggesting that the fixed antibodies (eluates) are, at least partially, consituted by antibodies similar to the anti-circulating antigen. These data reinfroce the hypothesis that renal injury in schistosomiasis is mediated through an immune complex disease. |
| Databáze: | OpenAIRE |
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