Co-infection with coxsackievirus A5 and norovirus GII.4 could have been the trigger of the first episode of severe acute encephalopathy in a six-year-old child with the intermittent form of maple syrup urine disease (MSUD)
| Autor: | Ákos Boros, Péter Pankovics, Enikő Ujhelyi, Sándor Kőmíves, Sarolta Dobner, Gábor Reuter, Nóra Bolba, Zoltán Liptai, György Várallyay, Petra Zsidegh |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Circulatory collapse Genotype viruses Coxsackievirus medicine.disease_cause 03 medical and health sciences Feces 0302 clinical medicine Medical microbiology Maple Syrup Urine Disease 030225 pediatrics Virology medicine Humans Child First episode Brain Diseases biology Coinfection Maple syrup urine disease Metabolic disorder Norovirus Metabolic acidosis General Medicine medicine.disease biology.organism_classification Enterovirus A Human 030104 developmental biology Female |
| Zdroj: | Archives of virology. 162(6) |
| ISSN: | 1432-8798 |
| Popis: | In this case study, a co-infection with coxsackievirus A5 (family Picornaviridae) and norovirus GII.4 (family Caliciviridae) was detected by RT-PCR in a faecal sample from a six-year-old girl with symptoms of severe acute encephalopathy subsequently diagnosed as the intermittent form of maple syrup urine disease (MSUD). The two co-infecting viruses, which had been detected previously, appeared to have triggered the underlying metabolic disorder. Here, we describe the genotyping of the viruses, as well as the chronological course, laboratory test results, and clinical presentation of this case, which included recurrent vomiting without diarrhoea, metabolic acidosis, unconsciousness, seizure and circulatory collapse, but with a positive final outcome. |
| Databáze: | OpenAIRE |
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