Adaptation of international guidelines for metastatic colorectal cancer: an asian consensus

Autor: Maximino Bello, Joong B. Ahn, Hwai L. Kong, Su Z. Zhang, Michael Shaw, Fortunato Ciardiello, Jin Li, Virote Sriuranpong, Li-Tzong Chen, Ka O. Lam, Ann-Lii Cheng, Aru W Sudoyo, Young Suk Park, Jaw-Yuan Wang, Gwo F. Ho, Brigette B.Y. Ma, Ashok K. Vaid, Clause Henning Köhne, Jun Zhang, Tian S. Liu, Catherine Teh, Tae Won Kim, Chaiyut Charoentum, Gilberto Lopes
Přispěvatelé: Cheng, Al, Li, J, Vaid, Ak, Ma, Bb, Teh, C, Ahn, Jb, Bello, M, Charoentum, C, Chen, Lt, de Lima Lopes G., Jr, Ho, Gf, Kong, Hl, Lam, Ko, Liu, T, Park, Y, Sriuranpong, V, Sudoyo, Aw, Wang, Jy, Zhang, J, Zhang, Sz, Ciardiello, Fortunato, Köhne, Ch, Shaw, M, Kim, Tw
Rok vydání: 2014
Předmět:
Oncology
Lung Neoplasms
Organoplatinum Compounds
Oxaloacetates
Colorectal cancer
Leucovorin
Cetuximab
medicine.disease_cause
Deoxycytidine
FOLFOX
Antineoplastic Combined Chemotherapy Protocols
Panitumumab
Liver Neoplasms
Gastroenterology
Antibodies
Monoclonal
Combined Modality Therapy
Magnetic Resonance Imaging
Bevacizumab
ErbB Receptors
Drug Combinations
Colonic Neoplasms
Practice Guidelines as Topic
KRAS
Fluorouracil
Guideline Adherence
medicine.drug
medicine.medical_specialty
Asia
Antibodies
Monoclonal
Humanized
Capecitabine
Proto-Oncogene Proteins p21(ras)
Internal medicine
Proto-Oncogene Proteins
medicine
Humans
Neoplasm Staging
Tegafur
business.industry
Rectal Neoplasms
Metastasectomy
medicine.disease
digestive system diseases
Surgery
Oxaliplatin
Oxonic Acid
ras Proteins
Camptothecin
business
Tomography
X-Ray Computed
Zdroj: Clinical colorectal cancer. 13(3)
ISSN: 1938-0674
Popis: Colorectal cancer (CRC) is among the most common cancers worldwide, but marked epidemiological differences exist between Asian and non-Asian populations. Hence, a consensus meeting was held in Hong Kong in December 2012 to develop Asia-specific guidelines for the management of metastatic CRC (mCRC). A multidisciplinary expert panel, consisting of 23 participants from 10 Asian and 2 European countries, discussed current guidelines for colon or rectal cancer and developed recommendations for adapting these guidelines to Asian clinical practice. Participants agreed that mCRC management in Asia largely follows international guidelines, but they proposed a number of recommendations based on regional 'real-world' experience. In general, participants agreed that 5-fluorouracil (5-FU) infusion regimens in doublets can be substituted with UFT (capecitabine, tegafur-uracil) and S1 (tegafur, 5-chloro-2,4-dihydroxypyridine and oxonic acid), and that the monoclonal antibodies cetuximab and panitumumab are recommended for KRAS wild type tumors. For KRAS mutant tumors, bevacizumab is the preferred biological therapy. FOLFOX (folinic acid, 5-FU, and oxaliplatin) is preferred for initial therapy in Asian patients. The management of mCRC is evolving, and it must be emphasized that the recommendations presented here reflect current treatment practices and thus might change as more data become available.
Databáze: OpenAIRE
Externí odkaz: