Discrimination, adjusted correlation, and equivalence of imprecise tests: application to glucose tolerance
| Autor: | Robert C Turner, R J Morris, Jonathan C. Levy, M S Hammersley |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Time Factors endocrine system diseases Physiology Endocrinology Diabetes and Metabolism Administration Oral Correlation Physiology (medical) Internal medicine Statistics medicine Humans Equivalence (measure theory) Aged Mathematics Plasma glucose Discriminant Analysis nutritional and metabolic diseases Fasting Glucose Tolerance Test Middle Aged Linear discriminant analysis Glucose Injections Intravenous Female |
| Popis: | Comparison studies between physiological tests are often unsatisfactory for assessing their ability to distinguish between subjects. We recommend a simple but comprehensive protocol, using duplicate testing, that compares tests using 1) the discriminant ratio (DR) between the underlying between- and within-subject SDs, 2) correlation coefficients adjusted for attenuation due to test imprecision, and 3) unbiased estimation of the underlying linear relationship between test results. The following five alternative methods for assessing glucose tolerance were compared: fasting plasma glucose (FPG) as a single sample or as the mean of three 5-min samples (FPG3); the 1- and 2-h glucose during a low-dose intravenous glucose infusion (CIG); and the 2-h plasma glucose from a 75-g oral glucose tolerance test (OGTT). All tests had similar DRs ranging from 2.6 to 4.2. The adjusted correlation between FPG and CIG tests approached unity, and those between OGTT and other tests were ∼0.9, showing that FPG3provides similar information to the OGTT. FPG concentrations of 6.0 and 7.1 were found equivalent to the 1985 World Health Organization OGTT thresholds for impaired glucose tolerance and diabetes (7.8 and 11.1 mmol/l). |
| Databáze: | OpenAIRE |
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