Case of vaso-occlusive retinopathy in Kikuchi-Fujimoto and lupus overlap syndrome
| Autor: | Nima Ghadiri, Miles Stanford |
|---|---|
| Rok vydání: | 2023 |
| Předmět: |
Adult
medicine.medical_specialty Fever Biopsy Lymph node biopsy Case Report 03 medical and health sciences 0302 clinical medicine Retinal Diseases medicine Axillary Lymphadenopathy Humans Lupus Erythematosus Systemic Mouth ulcers Histiocytic Necrotizing Lymphadenitis 030203 arthritis & rheumatology Systemic lupus erythematosus medicine.diagnostic_test business.industry Overlap syndrome General Medicine medicine.disease Dermatology 030221 ophthalmology & optometry Rituximab Female medicine.symptom Vasculitis business Retinopathy medicine.drug |
| Zdroj: | BMJ Case Rep |
| ISSN: | 1757-790X |
| Popis: | A 35-year-old woman presented with a constellation of systemic symptoms: rashes, weight loss, arthralgia and mouth ulcers. Six months afterwards, she experienced bilateral and sequential reduction in vision, and was found to have bilateral vaso-occlusive retinopathy, with critical macular ischaemia in the left eye. Her serological markers were consistent with a diagnosis of lupus. A lymph node biopsy confirmed Kikuchi-Fujimoto disease, a benign condition of unknown cause characterised by fever, cervical and axillary lymphadenopathy. Given that this overlap syndrome was associated with a number of systemic features and had affected the eyes, an immunosuppressive regime with rituximab was considered prudent. This rendered her vasculitis stable and non-progressive, and there were signs of partial retinal microvasculature recovery on optical coherence tomography angiography. There is increasing evidence of an overlap between Kikuchi-Fujimoto disease and systemic lupus erythematosus, which is associated with vaso-occlusive retinopathy. In these instances, a multidisciplinary approach is warranted, with consideration of appropriate treatment in order to prevent harmful sequelae of vasculitis. Our treatment with rituximab abated the disease process, although close follow-up is paramount to monitor results and side-effects of treatment. |
| Databáze: | OpenAIRE |
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