Adverse pregnancy outcomes and infant mortality after quadrivalent HPV vaccination during pregnancy

Autor: Christian Dehlendorff, Susanne K. Kjaer, Christian Munk, Anne Katrine Duun-Henriksen, Manrinder Kaur Tatla, Mette Tuxen Faber
Rok vydání: 2018
Předmět:
Adult
medicine.medical_specialty
Denmark
030231 tropical medicine
Population
Abortion
Logistic regression
03 medical and health sciences
Young Adult
0302 clinical medicine
Human Papillomavirus Recombinant Vaccine Quadrivalent
Types 6
11
16
18
Pregnancy
Infant Mortality
Odds Ratio
Medicine
Humans
030212 general & internal medicine
Registries
education
reproductive and urinary physiology
education.field_of_study
General Veterinary
General Immunology and Microbiology
business.industry
Proportional hazards model
Obstetrics
Papillomavirus Infections
Vaccination
Public Health
Environmental and Occupational Health
Infant
Newborn
Pregnancy Outcome
Infant
Stillbirth
medicine.disease
Infant mortality
Abortion
Spontaneous
Infectious Diseases
Logistic Models
Molecular Medicine
Gestation
Female
business
Zdroj: Vaccine. 37(2)
ISSN: 1873-2518
Popis: Background Few studies have studied the association between unintended human papillomavirus (HPV) vaccination and adverse pregnancy outcomes. This study set out to determine the association between HPV vaccination during pregnancy and subsequent risk of spontaneous abortion, stillbirth, and one-year infant mortality. Methods Population-based study including all pregnancies in Denmark (October 2006–December 2014) among women born 1975–1992. From nationwide health registries using the personal identification numbers, we obtained information on HPV vaccination, pregnancy outcomes, and infant mortality. The exposure window went from four weeks before conception date until 22 weeks of gestation for the outcome spontaneous abortion, and until birth for stillbirth and infant mortality outcomes. In the analyses of spontaneous abortion, we used time to event models, for stillbirth logistic regression models, and for infant mortality Cox regression was applied. Results We included 522,705 pregnancies for the outcome spontaneous abortion (7487 exposed to at least one dose during pregnancy); 351,878 births (5262 exposed to at least one dose during pregnancy) for the stillbirth; and 350,739 live births (5245 exposed to at least one dose during pregnancy) for infant mortality. No significantly increased rate of spontaneous abortion among women vaccinated during pregnancy compared with unvaccinated women was found. In addition, we found no association between HPV vaccination during pregnancy and stillbirth (adjusted odds ratio = 0.96 [95% CI: 0.57–1.61]), or infant mortality (adjusted hazard ratio = 0.94 [95% CI: 0.53–1.67]). A secondary analysis showed no association between number of doses and timing of administration (i.e. vaccination before or during pregnancy) and an increased risk of spontaneous abortion. Conclusion We found no increased risk of spontaneous abortion, stillbirth, or infant mortality following unintended HPV vaccination during pregnancy.
Databáze: OpenAIRE
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