Area under flow-volume loop may predict severe exacerbation in COPD patients with high grade of dyspnea
| Autor: | Ayşe Filiz Koşar, Aysegul Erinc, Mustafa Asim Demirkol, Burcu Arpinar Yigitbas, Celal Satici |
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| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry Male medicine.medical_specialty Exacerbation Physiology Logistic regression Severity of Illness Index Pulmonary function testing FEV1/FVC ratio Pulmonary Disease Chronic Obstructive Risk Factors Internal medicine Medicine Humans Risk factor Aged Retrospective Studies COPD medicine.diagnostic_test business.industry General Neuroscience Retrospective cohort study Middle Aged medicine.disease Prognosis Symptom Flare Up Dyspnea Female business |
| Zdroj: | Respiratory physiologyneurobiology. 294 |
| ISSN: | 1878-1519 |
| Popis: | Objective Exacerbations in patients with COPD may still be unpredictable, although the general risk factors have been well defined. We aimed to determine the role of a novel parameter, area under flow-volume loop, in predicting severe exacerbations. Methods In this single-centre retrospective cohort study, 81 COPD patients over 40 years of age with high grade of dyspnea (having a CAT score of ≥10) and a history of ≥1 moderate exacerbation in the previous year were included. Area under flow-volume curve (AreaFE%) was obtained from pulmonary function test graph and calculated from Matlab programme. Univariate and multivariate logistic regression analyses were performed to determine independent risk factors of the severe exacerbation. Results Patients with severe exacerbation (n = 70, 86.4 %) were older. They had lower FEV1%, FVC%, 6MWD, AreaFE% and higher CAT score than patients without exacerbation. After performing multivariate analysis, high CAT score and low AreaFE% value were found to be independent risk factors for severe exacerbation (OR: 1.12, 95 % CI: 1.065–1.724; p = 0.01 and OR: 1.18, 95 % CI: 0.732−0.974; p = 0.02). Conclusions We found that a low AreaFE% value was an independent risk factor in addition to a high CAT score and these both have an excellent discriminative ability in predicting the risk of severe exacerbation |
| Databáze: | OpenAIRE |
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