The replicative restriction of lymphocytotropic isolates of HIV-1 in macrophages is overcome by TGF-beta
| Autor: | Kathie Woods-Cook, Maja R. Walker, E Alteri, Robert Shipman, David Cox, Mcmaster Gary Kent, Nico Cerletti, Graham Bilbe, Janis K. Lazdins, Thomas Klimkait |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
viruses
medicine.medical_treatment T-Lymphocytes Immunology Immunoblotting Biology Virus Replication Virus Microbiology Transforming Growth Factor beta Virology HIV tropism medicine Macrophage Humans Tropism Cells Cultured Phagocytes Macrophages T lymphocyte Kinetics Infectious Diseases Cytokine Phenotype HIV-1 Cellular Tropism Transforming growth factor |
| Zdroj: | AIDS research and human retroviruses. 8(4) |
| ISSN: | 0889-2229 |
| Popis: | In vitro exposure of human blood monocyte-derived macrophages to T-cell tropic human immunodeficiency virus (HIV) isolates fails to establish a productive viral infection. Several studies have shown that such preferential HIV-1 replication in T cells or in mononuclear phagocytes (HIV tropism) may be determined by distinct viral characteristics. In the present study it was demonstrated that transforming growth factor-beta (TGF-beta), a factor known to be produced by platelets, macrophages, and other cells present at a wound site, can act as a mediator in overcoming the lymphocytotropic restriction of several well-characterized viral isolates of HIV-1 (i.e., LAV, Z84, pLAI, NY5). Macrophages infected with these isolates show cytopathic changes comparable to those seen upon infection with the monocytotropic isolate ADA. To achieve this effect with TGF-beta, the factor must be present after the infection period. The emerging virus retains its original cellular tropism. Based on these observations the authors propose a role for TGF-beta in the establishment and progression of HIV infection and disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|