Multifunctional Self-Adhesive Fibrous Layered Matrix (FiLM) for Tissue Glues and Therapeutic Carriers
| Autor: | Jung Suk Kim, Ye Eun Yoon, Jae Hyung Jang, Byung Gee Im |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Materials science
Polymers and Plastics Cell Survival Polyesters Genetic Vectors Green Fluorescent Proteins Biocompatible Materials Bioengineering Context (language use) 02 engineering and technology Gene delivery 01 natural sciences Biomaterials Jurkat Cells Mice chemistry.chemical_compound Drug Delivery Systems Materials Testing Materials Chemistry Animals Humans Composite material Mice Inbred ICR Wound Healing Tissue Engineering Tissue Scaffolds 010405 organic chemistry Tissue adhesives Dependovirus 021001 nanoscience & nanotechnology Electrospinning 0104 chemical sciences HEK293 Cells Self adhesive chemistry NIH 3T3 Cells Female Tissue Adhesives Adhesive 0210 nano-technology Wound healing Porosity Caprolactone |
| Zdroj: | Biomacromolecules. 18:127-140 |
| ISSN: | 1526-4602 1525-7797 |
| DOI: | 10.1021/acs.biomac.6b01413 |
| Popis: | Tissue adhesives, which inherently serve as wound sealants or as hemostatic agents, can be further augmented to acquire crucial functions as scaffolds, thereby accelerating wound healing or elevating the efficacy of tissue regeneration. Herein, multifunctional adherent fibrous matrices, acting as self-adhesive scaffolds capable of cell/gene delivery, were devised by coaxially electrospinning poly(caprolactone) (PCL) and poly(vinylpyrrolidone) (PVP). Wrapping the building block PCL fibers with the adherent PVP layers formed film-like fibrous matrices that could rapidly adhere to wet biological surfaces, referred to as fibrous layered matrix (FiLM) adhesives. The inclusion of ionic salts (i.e., dopamine hydrochloride) in the sheath layers generated spontaneously multilayered fibrous adhesives, whose partial layers could be manually peeled off, termed derivative FiLM (d-FiLM). In the context of scaffolds/tissue adhesives, both FiLM and d-FiLM demonstrated almost identical characteristics (i.e., sticky, mechanical, and performances as cell/gene carriers). Importantly, the single FiLM-process can yield multiple sets of d-FiLM by investing the same processing time, materials, and labor required to form a single conventional adhesive fibrous mat, thereby highlighting the economic aspects of the process. The FiLM/d-FiLM offer highly impacting contributions to many biomedical applications, especially in fields that require urgent aids (e.g., endoscopic surgeries, implantation in wet environments, severe wounds). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|