Early disappearance of alpha-transducin in light-induced photoreceptor degeneration in albino rats
| Autor: | J.-P. Faure, B. Thillaye, Mohammed Tarraf, Y. De Kozak, Massoud Mirshahi, Ahmad Razaghi |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Rhodopsin Light genetic structures Phosphodiesterase Inhibitors Blotting Western Fluorescent Antibody Technique Dark Adaptation Degeneration (medical) Autoantigens Immunoenzyme Techniques Cellular and Molecular Neuroscience Arrestin medicine Animals Photoreceptor Cells Transducin Antigens Eye Proteins G alpha subunit Retina biology Retinal Degeneration Antibodies Monoclonal Membrane Proteins Anatomy Sensory Systems Rats Cell biology Disease Models Animal Ophthalmology medicine.anatomical_structure Rats Inbred Lew biology.protein sense organs Alpha-Transducin Visual phototransduction |
| Zdroj: | Current Eye Research. 10:993-1000 |
| ISSN: | 1460-2202 0271-3683 |
| DOI: | 10.3109/02713689109020337 |
| Popis: | Progressive degeneration of retinal photoreceptor cells occurs in albino rats when exposed to continuous lighting. Three proteins involved in the phototransduction cascade were immunodetected in these cells after various durations of continuous illumination. We found that S-antigen (arrestin) and rhodopsin immunoreactivities persisted for 1-2 months during the degenerative process, whilst immunoreactivity of the alpha subunit of transducin totally disappeared between day 2 and day 4 of continuous light exposure. This suggests that continuous illumination could impair alpha-transducin synthesis, a possible causal factor of photoreceptor damage. |
| Databáze: | OpenAIRE |
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