Layer-specific integration of locomotion and sensory information in mouse barrel cortex
| Autor: | Fritjof Helmchen, Aman B. Saleem, Morio Hamada, Andreas Stäuble, Marie-Angela Wulf, Aslı Ayaz |
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| Přispěvatelé: | University of Zurich, Ayaz, Aslı |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Whiskers General Physics and Astronomy 02 engineering and technology Somatosensory system Mice Premovement neuronal activity 10064 Neuroscience Center Zurich lcsh:Science Neurons Multidisciplinary integumentary system Whisking in animals 021001 nanoscience & nanotechnology 3100 General Physics and Astronomy Models Animal Sensory processing 0210 nano-technology Locomotion animal structures Science 610 Medicine & health 1600 General Chemistry Genetics and Molecular Biology Sensory system Biology General Biochemistry Genetics and Molecular Biology Article Tactile stimuli 03 medical and health sciences Calcium imaging Sensorimotor processing 1300 General Biochemistry Genetics and Molecular Biology Physical Stimulation Animals 10242 Brain Research Institute General Chemistry Somatosensory Cortex Barrel cortex Mice Inbred C57BL 030104 developmental biology nervous system Touch Vibrissae General Biochemistry 570 Life sciences biology lcsh:Q Neuroscience |
| Zdroj: | Nature Communications Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019) Nature Communications, 10 (1) |
| ISSN: | 2041-1723 |
| Popis: | During navigation, rodents continually sample the environment with their whiskers. How locomotion modulates neuronal activity in somatosensory cortex, and how it is integrated with whisker-touch remains unclear. Here, we compared neuronal activity in layer 2/3 (L2/3) and L5 of barrel cortex using calcium imaging in mice running in a tactile virtual reality. Both layers increase their activity during running and concomitant whisking, in the absence of touch. Fewer neurons are modulated by whisking alone. Whereas L5 neurons respond transiently to wall-touch during running, L2/3 neurons show sustained activity. Consistently, neurons encoding running-with-touch are more abundant in L2/3 and they encode the run-speed better during touch. Few neurons across layers were also sensitive to abrupt perturbations of tactile flow during running. In summary, locomotion significantly enhances barrel cortex activity across layers with L5 neurons mainly reporting changes in touch conditions and L2/3 neurons continually integrating tactile stimuli with running. Nature Communications, 10 (1) ISSN:2041-1723 |
| Databáze: | OpenAIRE |
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