Radioprotective effects of Silymarin on the sperm parameters of NMRI mice irradiated with γ-rays
| Autor: | Ayoob Rostamzadeh, Mohammad Seify, Arash Shabani, Mohsen Mohammadi, Daryoush Fatehi, Babak Shekarchi |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Antioxidant Radioprotective Agent DNA damage medicine.medical_treatment Biophysics Radiation-Protective Agents Pharmacology Ionizing radiation Histones Mice 03 medical and health sciences 0302 clinical medicine Testis medicine Animals Radiology Nuclear Medicine and imaging Protamines chemistry.chemical_classification Reactive oxygen species 030219 obstetrics & reproductive medicine Radiation Radiological and Ultrasound Technology Spermatozoa Cytoprotection Sperm 030104 developmental biology chemistry Gamma Rays Sperm Motility Reactive Oxygen Species Spermatogenesis DNA Damage Silymarin |
| Zdroj: | Journal of Photochemistry and Photobiology B: Biology. 178:489-495 |
| ISSN: | 1011-1344 |
| Popis: | Free radicals and reactive oxygen species (ROS) are generated using various endogenous systems or from external sources such as exposure to different physiochemicals. Ionizing radiation damage to the cell can be caused by the direct or indirect effects of radiotherapy processes. Silymarin (SM), a flavanolignan compound, has been identified as a natural potent antioxidant with cytoprotection activities due to scavenging free radicals. The aim of the present study was to evaluate the radioprotective effect of SM on sperm parameters of mice induced by γ-rays. A total number of 40 adult, male NMRI mice were randomly divided into four equal groups. The control group was neither treated with SM nor irradiated by γ-rays. The second group was only irradiated with 2Gy of γ-rays. The third group was firstly treated with 50mg/kg of SM for 7 consecutive days, and one day later, last injections were irradiated by 2Gy of γ-rays. The fourth groups received only 50mg/kg of SM for 7 consecutive days. All the animals were treated intraperitoneally. Histopathological and morphometrical examinations were performed. The data were analyzed using ANOVA and Tukey post hoc test. A value of p |
| Databáze: | OpenAIRE |
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