Relationship between the use of Chinese herbal medicines and Sjögren syndrome risk among women with menopause: a retrospective cohort study
Autor: | Hanoch Livneh, Ming-Chi Lu, Ning-Sheng Lai, Chang-Kuo Wei, Hou-Hsun Liao, Tzung-Yi Tsai, Yu-Jung Chung |
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Rok vydání: | 2020 |
Předmět: |
China
medicine.medical_specialty General Mathematics Taiwan MEDLINE 030209 endocrinology & metabolism Sjögren syndrome Lower risk Cohort Studies 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Longitudinal Studies Retrospective Studies 030219 obstetrics & reproductive medicine business.industry Applied Mathematics Incidence (epidemiology) Hazard ratio Obstetrics and Gynecology Retrospective cohort study medicine.disease Menopause Sjogren's Syndrome Propensity score matching Female business Drugs Chinese Herbal |
Zdroj: | Menopause. 28:58-64 |
ISSN: | 1530-0374 |
DOI: | 10.1097/gme.0000000000001640 |
Popis: | Objective Menopausal women appear to report a higher risk of Sjogren syndrome (SS). Although Chinese herbal medicines (CHMs) are proven to lower SS risk, the scientific evidence of whether it can lessen the occurrence of SS among menopausal women is limited. This longitudinal cohort study aimed to clarify the relationship between CHMs use and SS risk in menopausal women. Methods Using a nationwide claims data, we enrolled 31,917 women with first-time diagnosed menopause who simultaneously were free of SS between 2000 and 2007. Among them, we randomly selected 12,757 CHMs users and 12,757 non-CHMs users using propensity scores matching. All participants were followed until the end of 2012 to record SS incidence. The hazard ratio of SS with regard to CHMs use was estimated using the Cox proportional hazards regression model. Results In the follow-up period, 589 CHMs users and 644 non-CHMs users developed SS, representing incidence rates of 5.12 and 6.40, respectively, per 1,000 person-years. CHMs use was associated with a 21% lower subsequent risk of SS (adjusted hazard ratio, 0.79; 95% CI, 0.71-0.89). Six commonly prescribed CHMs were discovered to be associated with lower SS risk: Ge-Gen-Tang, Zhi-Gan-Cao-Tag, Da-Huang, Ye-Jiao-Teng, Tian-Hua-Fen, and Bo-Zi-Ren. Conclusions A statistically significant association was found between CHMs use and lower risk of SS onset in menopausal women, suggesting that CHMs could be considered to integrate it into conventional therapy to reduce subsequent SS risk for menopausal women. |
Databáze: | OpenAIRE |
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