Activation of Mononuclear Immune Cells in Response to Staphylococcal Lipoteichoic Acid
| Autor: | H.L. Ko, H. Burrichter, J. Beuth, G. Pulverer, Yukio Ohshima, K. Oette |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Lipopolysaccharides
Interleukin 2 Tumor Necrosis Factor-alpha medicine.drug_class Staphylococcus Immunology Receptors Interleukin-2 Biology Monoclonal antibody Peripheral blood mononuclear cell In vitro Microbiology Teichoic Acids Mice Immune system Leukocytes Mononuclear Tumor Cells Cultured medicine Animals Female Tumor necrosis factor alpha Lipoteichoic acid Receptor medicine.drug |
| Zdroj: | Zentralblatt für Bakteriologie. 275:374-381 |
| ISSN: | 0934-8840 |
| DOI: | 10.1016/s0934-8840(11)80303-8 |
| Popis: | Summary The goal of the present study was to evaluate the influence of staphylococcallipoteichoic acid (L T A) on the activation of mononuclear immune cells. A murine tumor necrosis-like factor (TNF-like) was induced in the sera of CD-1 mice which had been primed with heat/formalin-inactivated Propionibacterium avidum KP-40 and subsequently exposed to L T A extracted from Staphylococcus saprophyticus strain S 1. Monoclonal antibody against murine TNF (anti-TNF) significantly inhibited the cytostatic activity of mice sera against transformed L-929 cells. Freshly isolated lymphocytes did not display interleukin 2 (Il-2) receptors, but receptors were expressed on Con A incubated cells and in significantly higher numbers after coexposure to staphylococcal LTA in vitro. Since the induction of TNF (macrophages) and Il-2 receptors (lymphocytes) represent stimulation of the mononuclear immune system, staphylococcal LTA may be considered to be an immunomodifier. |
| Databáze: | OpenAIRE |
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