Antidepressive effects of ginsenoside Rg1 via regulation of HPA and HPG axis

Autor: Shi-Feng Chu, Jin-Feng Hu, Mei-Jin Zhang, Qian Huang, Nai-Hong Chen, Jun-Tian Zhang, Zheng Mou
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
Hypothalamo-Hypophyseal System
Time Factors
Ginsenosides
Hypothalamic–pituitary–gonadal axis
Motor Activity
Rats
Sprague-Dawley
03 medical and health sciences
Food Preferences
Mice
0302 clinical medicine
Glucocorticoid receptor
Receptors
Glucocorticoid
Internal medicine
Testis
medicine
Animals
Increased serum testosterone level
Testosterone
Swimming
Pharmacology
Behavior
Animal
Dose-Response Relationship
Drug
business.industry
Depression
General Medicine
Tail suspension test
Antidepressive Agents
Androgen receptor
Affect
Disease Models
Animal
030104 developmental biology
Endocrinology
Hindlimb Suspension
Receptors
Androgen
business
Corticosterone
Sleep
Orchiectomy
030217 neurology & neurosurgery
Glucocorticoid
Stress
Psychological
Behavioural despair test
medicine.drug
Zdroj: Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 92
ISSN: 1950-6007
Popis: Background Hypothalamic–pituitary–adrenal (HPA) axis hyperactivity is a well-established pathological feature of major depression, accompanied by the persistent increase of glucocorticoid level and the dysfunction of hypothalamic–pituitary–gonadal (HPG) axis. Ginsenoside Rg1 (Rg1) is one of the most active ingredients of Panax ginseng, which has various biological activity. Objective This study aimed to investigate the antidepressive effects of Rg1 and elucidate its impact on neuroendocrine system. Methods The antidepressive effects of Rg1 were first analysed in mice, and was further identified in the chronic-unpredictable-mild-stress (CUMS) model and the gonadectomized (GDX) model. The effects of Rg1 on depression-like behaviour were analysed by the forced swimming test (FST), tail suspension test (TST), sucrose preference test, and measurement of pentobarbital-induced sleep. The serum corticosterone and testosterone levels were detected by ELISA. The protein levels of glucocorticoid receptor (GR) and androgen receptor (AR) were analysed by western blot and immunohistochemistry analysis. Results Rg1 significantly decreased the immobility time of mice in FST and TST. Furthermore, Rg1 alleviated anhedonia and hopelessness, decreased serum corticosterone level, and increased serum testosterone level, and the GR protein level in the PFC and hippocampus of the CUMS-treated rats. Moreover, Rg1 improved sleep disruption, down-regulated the serum corticosterone level, and increased AR protein level in the PFC of the GDX-treated mice. Conclusion Together, these studies suggest that Rg1 displayed antidepressant activity through the modulation of the HPA and the HPG axis. These findings provide new mechanism involved in the antidepressive effects of Rg1 and propose theoretical clues for clinical therapies.
Databáze: OpenAIRE
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