Changes in cerebral inositol-1-phosphate concentrations in LiCl-treated rats: regional and strain differences
| Autor: | Juhani Tarhanen, L. Pazdernik Thomas, Stanley R. Nelson, Maija-Riitta Hirvonen, Kai M. Savolainen, Fred E. Samson |
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| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Lithium (medication) Inositol Phosphates Lithium Biochemistry Hippocampus Gas Chromatography-Mass Spectrometry Cellular and Molecular Neuroscience chemistry.chemical_compound Equivalent Inbred strain Chlorides Species Specificity Internal medicine medicine Pi Animals Inositol Tissue Distribution Receptor Cerebral Cortex Brain Rats Inbred Strains General Medicine Metabolism Rats Endocrinology chemistry Lithium chloride Caudate Nucleus Lithium Chloride medicine.drug |
| Zdroj: | Neurochemical research. 15(5) |
| ISSN: | 0364-3190 |
| Popis: | LiCl-induced (5 mEq/kg) regional differences in the cerebral phosphoinositide (PI) cycle were studied by measuring inositol-1-phosphate (Ins-1-P), an, intermediate in the PI cycle, in male Sprague Dawley and Han/Wistar rats by gas chromatography/mass spectrometry. Control Ins-1-P levels were higher frontally than caudally in both rat strains. LiCl increased Ins-1-P levels 1.8 to 7.4 fold in different, regions of brain of Sprague Dawley rats but only 1.2 to 1.8 fold in Han/Wistar rats. This strain difference offers a way to compare the effects of lithium on PI metabolism versus receptor-G protein-phospholipase C coupling mechanisms. |
| Databáze: | OpenAIRE |
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