Cytomegalovirus impairs antiviral CD8+ T cell immunity by recruiting inflammatory monocytes
| Autor: | Grace M. Wynn, Edward S. Mocarski, Lisa P. Daley-Bauer |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adoptive cell transfer
Chemokine Muromegalovirus animal diseases Immunology CCL2 CD8-Positive T-Lymphocytes Nitric Oxide Monocytes Article Cell Line 03 medical and health sciences Mice Viral Proteins 0302 clinical medicine Immune system Cytotoxic T cell Immunology and Allergy Animals CCL13 Chemokine CCL2 030304 developmental biology Mice Knockout 0303 health sciences biology Herpesviridae Infections Acquired immune system 3. Good health Mice Inbred C57BL Infectious Diseases Chemokines CC biology.protein CC chemokine receptors 030215 immunology |
| Zdroj: | Immunity. 37(1) |
| ISSN: | 1097-4180 |
| Popis: | Summary Inflammatory monocytes are key early responders to infection that contribute to pathogen-host interactions in diverse ways. Here, we report that the murine cytomegalovirus-encoded CC chemokine, MCK2, enhanced CCR2-dependent recruitment of these cells to modulate antiviral immunity, impairing virus-specific CD8 + T cell expansion and differentiation into effector cytotoxic T lymphocytes, thus reducing the capacity to eliminate viral antigen-bearing cells and slowing viral clearance. Adoptive transfer of inflammatory monocytes into Ccr2 −/− Ccl2 −/− mice impaired virus antigen-specific clearance. Cytomegalovirus therefore enhances a natural CCR2-dependent immune regulatory network to modulate adaptive immunity via nitric oxide production, reminiscent of the monocytic subtype of myeloid-derived suppressor cells primarily implicated in cancer immunomodulation. |
| Databáze: | OpenAIRE |
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