In vivo evaluation of thiol-functionalized superparamagnetic iron oxide nanoparticles
| Autor: | Fabio Furlan Ferreira, Tatiane N. Britos, Giuliana Petri, Bruno Machado Bertassoli, Carlos E. de Castro, Fernando Luiz Affonso Fonseca, Paula S. Haddad |
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| Rok vydání: | 2019 |
| Předmět: |
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Materials science Biocompatibility Coprecipitation Iron Static Electricity Iron oxide Nanoparticle Bioengineering Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Biomaterials chemistry.chemical_compound X-Ray Diffraction Spectroscopy Fourier Transform Infrared Animals Sulfhydryl Compounds Particle Size Magnetite Nanoparticles Mice Inbred BALB C 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Mechanics of Materials Drug delivery Hydrodynamics Cystine Nanomedicine Magnetic nanoparticles Nanocarriers 0210 nano-technology Spleen |
| Zdroj: | Materials Science and Engineering: C. 99:171-179 |
| ISSN: | 0928-4931 |
| Popis: | This article describes the synthesis, characterization and in vivo cytotoxic evaluation of thiol-functionalized superparamagnetic iron oxide magnetic nanoparticles (SPIONs). They have been employed as potential vehicles for a large number of biomedical applications, such as drug delivery. Fe3O4 nanoparticles were synthesized by coprecipitation of iron salts and coated with L-cysteine. The physicochemical, morphological, and magnetic properties of Cys-Fe3O4 nanoparticles were characterized by different experimental techniques. To evaluate their applicability in nanomedicine we evaluated their cytotoxicity using Balb/C mice. The results show that Cys-SPIONs are good candidates as nanocarriers in biomedical applications. |
| Databáze: | OpenAIRE |
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