The growth response to tumour necrosis factor alpha of human gynaecological cancer cell lines
| Autor: | John O. White, J.S. Beesley, A. Stackpoole, P.L. Kirby, W. P. Soutter, Satoru Takeda |
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| Rok vydání: | 1998 |
| Předmět: |
Cell type
Genital Neoplasms Female medicine.medical_treatment Immunology Uterine Cervical Neoplasms Biology Biochemistry Polymerase Chain Reaction Antibodies Receptors Tumor Necrosis Factor Flow cytometry Cell surface receptor medicine Tumor Cells Cultured Immunology and Allergy Humans Receptor Molecular Biology Ovarian Neoplasms medicine.diagnostic_test Tumor Necrosis Factor-alpha Hematology medicine.disease Flow Cytometry Endometrial Neoplasms Cytokine Cell culture Cancer research Tumor necrosis factor alpha Female Ovarian cancer Cell Division |
| Zdroj: | Cytokine. 10(6) |
| ISSN: | 1043-4666 |
| Popis: | The cytokine tumour necrosis factor alpha (TNF-alpha) is implicated in the regulation of diverse gynaecological cell types, its biological activity being potentially mediated by two distinct cell surface receptors (TNFR) of molecular weight 55 and 75 kDa, respectively. In this study the sensitivity to the growth regulatory properties of TNF-alpha of a panel of human cervical, endometrial and ovarian cancer cell lines was investigated in relation to the expression and biological activity of the 55- and 75-kDa receptor. There was no evidence of expression or function of the 75-kDa receptor in any of the cell lines tested. The expression and biological activity of the 55-kDa receptor was demonstrated in each TNF sensitive cell line, with one exception, the HOG-1 cervical cancer cell line. The data suggest that the 55-kDa receptor mediates the cellular response to TNF-alpha in sensitive gynaecological cancer cell lines but raises the possibility of the presence of a distinct receptor in HOG-1 cells. |
| Databáze: | OpenAIRE |
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