Conserved cell types with divergent features between human and mouse cortex
| Autor: | Jeff Goldy, Sheana Parry, Jeremy A. Miller, Brian Long, Susan M. Sunkin, Saroja Somasundaram, Rebecca D. Hodge, Hongkui Zeng, Aaron Oldre, Kimberly A. Smith, Zoe Maltzer, Brian D. Aevermann, Mohamed Keshk, Jeroen Eggermont, Ed Lein, Daniel Hirschstein, Darren Bertagnolli, Jennie L. Close, Osnat Penn, John W. Phillips, Rachel A. Dalley, Allan R. Jones, Ahmed Mahfouz, Olivia Fong, Allison Beller, Soraya I. Shehata, Thuc Nghi Nguyen, Jeffrey G. Ojemann, Shannon Reynolds, Eliza Barkan, Michael Tieu, Christof Koch, Michael Hawrylycz, Songlin Ding, Richard H. Scheuermann, Ryder P. Gwinn, Elliot R. Thomsen, Medea McGraw, Emma Garren, Christine Rimorin, Lydia Ng, Boudewijn P. F. Lelieveldt, C. Dirk Keene, Amy Bernard, Richard G. Ellenbogen, Rafael Yuste, David Feng, Boaz P. Levi, Trygve E. Bakken, Tamara Casper, Bosiljka Tasic, Aaron Szafer, Nick Dee, Nadiya V. Shapovalova, Kanan Lathia, Lucas T. Graybuck, Charles Cobbs, Julie Nyhus, Thomas Höllt, Zizhen Yao, Krissy Brouner, Andrew L. Ko |
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| Rok vydání: | 2018 |
| Předmět: |
0303 health sciences
Cell type Neocortex Cellular architecture Middle temporal gyrus Cell Human brain Biology 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Cerebral cortex medicine Neuroscience Nucleus 030217 neurology & neurosurgery 030304 developmental biology |
| Popis: | Elucidating the cellular architecture of the human neocortex is central to understanding our cognitive abilities and susceptibility to disease. Here we applied single nucleus RNA-sequencing to perform a comprehensive analysis of cell types in the middle temporal gyrus of human cerebral cortex. We identify a highly diverse set of excitatory and inhibitory neuronal types that are mostly sparse, with excitatory types being less layer-restricted than expected. Comparison to a similar mouse cortex single cell RNA-sequencing dataset revealed a surprisingly well-conserved cellular architecture that enables matching of homologous types and predictions of human cell type properties. Despite this general conservation, we also find extensive differences between homologous human and mouse cell types, including dramatic alterations in proportions, laminar distributions, gene expression, and morphology. These species-specific features emphasize the importance of directly studying human brain. |
| Databáze: | OpenAIRE |
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