Pharmacokinetics of glaucine after intravenous and oral administrations and detection of systemic aporphine alkaloids after ingestion of tulip poplar shavings in horses

Autor:	Joanne E. Haughan, Jaclyn R. Missanelli, Youwen You, Darko Stefanovski, Lawrence R. Soma, Mary A. Robinson
Rok vydání:	2022
Předmět:	Pharmacology Eating Aporphines Cross-Over Studies General Veterinary Area Under Curve Injections Intravenous Anti-Inflammatory Agents Administration Oral Animals Tulipa Horses Half-Life
Zdroj:	Journal of Veterinary Pharmacology and Therapeutics. 45:273-282
ISSN:	1365-2885 0140-7783
DOI:	10.1111/jvp.13057
Popis:	Glaucine, an aporphine alkaloid with anti-tussive, anti-inflammatory, and anti-nociceptive properties, has been identified in post-race samples from racehorses. To investigate pharmacokinetics of glaucine in horses, a three-way crossover study of intravenous and oral glaucine (0.1 mg/kg) and orally administered tulip poplar shavings (50 g shavings = 0.001 mg/kg glaucine) was performed in six horses. A two-compartment model best described IV administration with alpha (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df5273f927bd3d856942af7b34fb96c https://doi.org/10.1111/jvp.13057 Zobrazit plný text záznamu Plný text