Hantavirus Pulmonary Syndrome, Central Plateau, Southeastern, and Southern Brazil
Autor: | Charlotte M Harsi, Luiz Tadeu Moraes Figueiredo, Glauciane G de-Figueiredo, Ricardo L M de-Sousa, Luiza T M de-Souza, Renato P de-Souza, Teresa Keico Nagasse-Sugahara, Carla Torres Braconi, Luiz Eloy Pereira, Akemi Suzuki, Alessandra Abel Borges, Ivani Bisordi, Marcos Lázaro Moreli, Alex Martins Machado, Paolo M de-Andrade-Zanotto |
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Rok vydání: | 2009 |
Předmět: |
Microbiology (medical)
Orthohantavirus Genes Viral Juquitiba virus Rodent Epidemiology viruses education lcsh:Medicine Virulence Rodentia hantavirus pulmonary syndrome Biology Antibodies Viral Communicable Diseases Emerging Genetic analysis Virus lcsh:Infectious and parasitic diseases Viral Proteins Blood serum Araraquara virus biology.animal Animals Humans lcsh:RC109-216 Phylogeny DNA Primers Hantavirus geography Hantavirus pulmonary syndrome research Plateau geography.geographical_feature_category Base Sequence fungi lcsh:R Nucleocapsid Proteins Virology Infectious Diseases RNA Viral Brazil |
Zdroj: | Emerging Infectious Diseases, Vol 15, Iss 4, Pp 561-567 (2009) Emerging Infectious Diseases |
ISSN: | 1080-6059 1080-6040 |
DOI: | 10.3201/eid1504.080289 |
Popis: | This syndrome is an increasing health problem because of human encroachment into habitats of rodent reservoirs. Hantavirus pulmonary syndrome (HPS) is an increasing health problem in Brazil because of encroachment of sprawling urban, agricultural, and cattle-raising areas into habitats of subfamily Sigmodontinae rodents, which serve as hantavirus reservoirs. From 1993 through June 2007, a total of 884 cases of HPS were reported in Brazil (case-fatality rate 39%). To better understand this emerging disease, we collected 89 human serum samples and 68 rodent lung samples containing antibodies to hantavirus from a 2,500-km-wide area in Brazil. RNA was isolated from human samples and rodent tissues and subjected to reverse transcription–PCR. Partial sequences of nucleocapsid protein and glycoprotein genes from 22 human and 16 rodent sources indicated only Araraquara virus and Juquitiba virus lineages. The case-fatality rate of HPS was higher in the area with Araraquara virus. This virus, which may be the most virulent hantavirus in Brazil, was associated with areas that have had greater anthropogenic changes. |
Databáze: | OpenAIRE |
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