Expression of FFAR3 and FFAR4 Is Increased in Gastroesophageal Reflux Disease

Autor:	Jakub Fichna, Karolina Niewinna, Marcin Talar, Julia B. Krajewska, Ewa Małecka-Panas, Adrian Bartoszek, Anna Mokrowiecka, Maciej Sałaga, Agata Binienda, Aleksandra Tarasiuk, Agnieszka Wierzchniewska-Ławska, Paula Mosińska, Katarzyna Dziedziczak, Adam Fabisiak
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	medicine.medical_specialty Nerd gastroesophageal reflux disease lcsh:Medicine Inflammation Disease Gastroenterology Article Pathogenesis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Esophagus Receptor business.industry lcsh:R Reflux General Medicine medicine.disease digestive system diseases medicine.anatomical_structure inflammation 030220 oncology & carcinogenesis GERD 030211 gastroenterology & hepatology free fatty acid receptor medicine.symptom business
Zdroj:	Journal of Clinical Medicine Journal of Clinical Medicine, Vol 9, Iss 4111, p 4111 (2020) Volume 9 Issue 12
ISSN:	2077-0383
Popis:	Background: The negative impact of a high-fat diet on the course of gastroesophageal reflux disease (GERD) has been previously reported. Free fatty acid receptors (FFARs) may be mediators of this phenomenon. The aim of this study was to characterize the role of FFARs in the course of nonerosive (NERD) and erosive (ERD) reflux disease. Methods: Collectively, 73 patients (62 with GERD and 11 healthy controls (HCs)) were recruited to the study. Esophageal biopsies were drawn from the lower third of the esophagus and kept for further experiments. Quantitative, real-time polymerase chain reaction was used to assess the expression of FFAR1, FFAR2, FFAR3, and FFAR4 in biopsies. Histological evaluation of dilated intracellular spaces (DISs) was also performed. Results: FFAR3 exhibited the highest expression, and FFAR4 exhibited the lowest expression in all esophageal samples. Higher relative expression of FFAR1 and FFAR2 and significantly higher expression of FFAR3 (p = 0.04) was noted in patients with GERD compared to respective HCs. Patients with nonerosive GERD (NERD) presented higher expression of all FFARs compared to patients with erosive GERD (ERD) and respective HCs. Interestingly, in patients with ERD, the expression of FFAR3 was lower than in HCs. Significant, weak, positive correlation was found for FFAR3 and FFAR4 expression and DIS scores (r = 0.36, p < 0.05 for FFAR 3, and r = 0.39, p < 0.05 for FFAR4). Conclusions: In this study, we show that FFARs may play a role in GERD pathogenesis, particularly in the NERD type. It may be assumed that FFARs, in particular FFAR3 and FFAR4, may have diagnostic and therapeutic potential in GERD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df206c7a826b1851b85322e4a027f65 http://europepmc.org/articles/PMC7766740 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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