Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes

Autor: Vogelezang, Suzanne, Bradfield, Jonathan P., Johansson, Stefan, Stergiakouli, Evie, Thiering, Elisabeth, Pennell, Craig E., Ahluwalia, Tarunveer S., Karhunen, Ville, Scholz, Markus, Liu, Xueping, Iñiguez, Carmen, Raitakari, Olli T., Bacelis, Jonas, Schnurr, Theresia M., Lakka, Timo A., Ntalla, Ioanna, Lind, Mads V., Lauritzen, Lotte, Herrala, Sauli, Lin, Frederick T. J., Frithioff-Bøjsøe, Christine, Beaumont, Robin N., Zafarmand, Mohammed H., Rzehak, Peter, Bilbao, Jose R., Junna, Nella, Vonk, Judith M., Rifas-Shiman, Sheryl L., Janjanam, Vimala D., Knol, Maria J., Ramdas, Shweta, Beilin, Lawrie, Bønnelykke, Klaus, Casas, Maribel, Eriksson, Johan G., Escribano, Joaquin, Evans, Tavia E., Gehring, Ulrike, Geller, Frank, Grote, Veit, Gruszfeld, Darek, Hakonarson, Hakon, Hattersley, Andrew T., Have, Christian T., Geoffrey Hayes, M., Heinrich, Joachim, Helgeland, Øvind, Holloway, Jhon, Joro, Raimo, Juodakis, Julius, Knight, Bridget A., Koletzko, Bert, Körner, Antje, Langhendries, Jean-Paul, Leinonen, Jaakko T., Lindi, Virpi, Lund, Morten A. V., Lye, Stephen, Melbye, Mads, Michaelsen, Kim F., Morgen, Camilla S., Niinikoski, Harri, Pahkala, Katja, Panoutsopoulou, Kalliope, Pedersen, Oluf, Rivadeneira, Fernando, Santa-Marina, Loreto, Schaik, Barbera D. C., Scholtens, Denise, Sebert, Sylvain, Tamayo, Ibon, Timpson, Nicholas J., Torrent, Maties, Uitterlinden, André G., Vaudel, Marc, Verduci, Elvira, Vinding, Rebecca, Vogel, Mandy, Zeggini, Eleftheria, Brown, Christopher, Adams, Hieab H. H., Karmaus, Wilfried, Hivert, Marie-France, Koppelman, Gerard H., Widén, Elisabeth, Fernandez-Jimenez, Nora, Waldenberger, Melanie, Vrijkotte, Tanja G. M., Freathy, Rachel M., Holm, Jens-Christian, Lowe, William L., Grarup, Niels, Hansen, Torben, Dedoussis, George V., Atalay, Mustafa, Nohr, Ellen A., Jacobsson, Bo, Pitkänen, Niina, Vrijheid, Martine, Feenstra, Bjarke, Kiess, Wieland, Jarvelin, Marjo-Riita, Bisgaard, Hans, Wang C, Carol, Standl, Marie, McCarthy, Mark I., Pourcain, Beate St, Njølstad, Pål R., Grant, Struan F. A., Felix, Janine F., Jaddoe, Vincent W. V.
Přispěvatelé: Epidemiology, Pediatrics, Radiology & Nuclear Medicine, Internal Medicine, Clinical Genetics, Groningen Research Institute for Asthma and COPD (GRIAC)
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: BMC Med. Genomics 15:124 (2022)
BMC Medical Genomics, 15(1):124. BioMed Central Ltd.
2022, ' Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes ', BMC Medical Genomics, vol. 15, no. 124, pp. 124 . https://doi.org/10.1186/s12920-022-01281-1
Vogelezang, S, Bradfield, J P, Early Growth Genetics Consortium, Ahluwalia, T V S, Liu, X, Schnurr, T M, Frithioff-Bøjsøe, C, Bønnelykke, K, Lind, M V, Lauritzen, L, Michaelsen, K F, Lund, M A V, Melbye, M, Morgen, C S, Pedersen, O B, Holm, J-C, Grarup, N, Hansen, T, Nohr, E A, Bisgaard, H, Grant, S F A, Felix, J F & Jaddoe, V W V 2022, ' Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes ', BMC Medical Genomics, vol. 15, 124 . https://doi.org/10.1186/s12920-022-01281-1
BMC Med Genomics
BMC Medical Genomics, 15:124. BioMed Central Ltd.
BMC Medical Genomics
ISSN: 1471-2350
1755-8794
DOI: 10.1186/s12920-022-01281-1
Popis: Background Head circumference is associated with intelligence and tracks from childhood into adulthood. Methods We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age. Results Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes. Conclusions The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.
Databáze: OpenAIRE
Externí odkaz: