Complex coacervates as artificial membraneless organelles and protocells
| Autor: | Nan-Nan Deng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Fluid Flow and Transfer Processes
Protocell chemistry.chemical_classification Coacervate Biomolecule 010401 analytical chemistry Microfluidics Biomedical Engineering Nanotechnology 02 engineering and technology 021001 nanoscience & nanotechnology Condensed Matter Physics 01 natural sciences Polyelectrolyte 0104 chemical sciences Colloid and Surface Chemistry chemistry Organelle General Materials Science 0210 nano-technology Perspectives |
| Zdroj: | Biomicrofluidics |
| Popis: | Complex coacervates are water droplets dispersed in water, which are formed by spontaneous liquid-liquid phase separation of an aqueous solution of two oppositely charged polyelectrolytes. Similar to the membraneless organelles that exist in biological cells, complex coacervate droplets are membraneless and have a myriad of features including easy formation, high viscosity, selective encapsulation of biomolecules, and dynamic behaviors in response to environmental stimuli, which make coacervates an excellent option for constructing artificial membraneless organelles. In this article, I first summarize recent advances in artificial compartments that are built from coacervates and their response to changes in the surrounding environment and then show the advantages of microfluidic techniques in the preparation of monodisperse coacervates and encapsulation of coacervates in droplets and liposomes to construct complex cell-like compartments, and finally discuss the future challenges of such membraneless aqueous compartments in cell mimics and origin of life. |
| Databáze: | OpenAIRE |
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