The interpretation of exhaled nitric oxide values in children with asthma depends on the degree of bronchoconstriction and the levels of asthma severity
| Autor: | Anna Janas, Iwona Stelmach, Eusebio Makandjou-Ola, Włodzimierz Stelmach, Tomasz Grzelewski, Konrad Witkowski, Paweł Majak, Joanna Jerzyńska, Aleksandra Grzelewska, Rafał Stelmach |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry Male medicine.medical_specialty Adolescent medicine.drug_class Cross-sectional study Bronchoconstriction Critical Care and Intensive Care Medicine Nitric Oxide Severity of Illness Index Bronchodilator Internal medicine Forced Expiratory Volume Severity of illness Medicine Humans Albuterol Child Asthma Retrospective Studies medicine.diagnostic_test business.industry General Medicine respiratory system medicine.disease respiratory tract diseases Bronchodilator Agents Cross-Sectional Studies Breath Tests Anesthesia Exhaled nitric oxide Salbutamol Female medicine.symptom business Biomarkers medicine.drug |
| Zdroj: | Respiratory care. 59(9) |
| ISSN: | 1943-3654 |
| Popis: | BACKGROUND: The clinical implications of fractional exhaled nitric oxide (FENO) measurements in childhood asthma are unclear. We aimed to evaluate the relationship between the level of exhaled nitric oxide and pre-bronchodilator FEV1 and the change in FEV1 after bronchodilator in children with asthma. METHODS: This was a retrospective, cross-sectional study. We evaluated data from medical documentation of children with asthma with special attention to FENO results, asthma severity, FEV1 (% predicted), and bronchial reversibility test. RESULTS: Four hundred and five subjects (age 6–18 y) completed the study. Median levels of FENO increased linearly with subjects9 age (P = .03). We found a nonlinear trend of pre-bronchodilator FEV1 across 4 quartiles of FENO in episodic and mild asthma; we observed lower pre-bronchodilator FEV1 in children with higher FENO, but only up to the FENO value of 35.4 ppb; in children with FENO value > 35.4 ppb, pre-bronchodilator FEV1 was increased. We found a linear increasing trend of change from baseline (after 400 μg of salbutamol) in FEV1 across FENO categories in children with moderate asthma. CONCLUSIONS: Our results suggest a need to measure FENO before as well as after spirometry. Consequently, in children with asthma with bronchial obstruction, we suggest assessing FENO after short-acting β2 agonists as well. (ClinicalTrials.gov registration NCT00815984.) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|