COST-EFFECTIVENESS EVALUATION OF PREHOSPITAL THROMBOLYSIS WITH TENECTEPLASE
| Autor: | E. V. Derkach, V. V. Omel'yanovskiy, Tereshchenko Sn, P. M. Khaylov |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system thrombolysis myocardial infarction with st segment elevation Cost effectiveness medicine.medical_treatment Tenecteplase RM1-950 Bolus (medicine) Internal medicine чрескожное коронарное вмешательство medicine ST segment Diseases of the circulatory (Cardiovascular) system Pharmacology (medical) Myocardial infarction cardiovascular diseases тенектеплаза tenecteplase business.industry lcsh:RM1-950 percutaneous coronary intervention Percutaneous coronary intervention Thrombolysis medicine.disease реперфузия reperfusion lcsh:Therapeutics. Pharmacology surgical procedures operative lcsh:RC666-701 RC666-701 Conventional PCI тромболизис Cardiology инфаркт миокарда с подъемом ST Therapeutics. Pharmacology Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 7, Iss 2, Pp 145-150 (2016) |
| ISSN: | 2225-3653 1819-6446 |
| Popis: | Aim. To evaluate clinical and cost effectiveness of different reperfusion strategies in myocardial infarction with ST segment elevation (STEMI), including pre-hospital thrombolysis with tenecteplase. Material and methods. Methods of cost-effectiveness analysis and economic modeling were used to calculate the costs of reperfusion in STEMI, expected number of life gains, the cost of life gains depending on reperfusion strategy (no reperfusion, percutaneous coronary intervention (PCI), prehospital thrombolysis, hospital thrombolysis). Results. In accordance to analysis results and from economic point of view, the most effective strategy is primary PCI in patients within "therapeutic window" and pre-hospital thrombolysis in the remaining patients with STEMI. More complex strategy of patients flow control with patient division into groups of primary PCI, pre-hospital thrombolysis and hospital thrombolysis lead to decrease in reperfusion costs efficacy. Conclusion. The reperfusion model with primary PCI in the first 120 minutes after STEMI symptoms onset, and pre-hospital thrombolysis with bolus thrombolytic administration, when PCI is not possible in this period, is the most effective economically and in respect on mortality reduction in patients with STEMI. |
| Databáze: | OpenAIRE |
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