Comparative evolutionary genetics of deleterious load in sorghum and maize
| Autor: | Nonoy Bandillo, Patrick J. Brown, Todd C. Mockler, Jeffrey Ross-Ibarra, Samuel Fernandes, Jhonathan P. R. dos Santos, Elizabeth A. Cooper, Nadia Shakoor, M. Taylor Perkins, Roberto Lozano, Ravi Valluru, Michael A. Gore, Edward S. Buckler, Markus G Stetter, Elodie Gazave |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
0301 basic medicine Genetics Comparative genomics education.field_of_study biology Human evolutionary genetics Population Population genetics food and beverages Genomics Plant Science Sorghum biology.organism_classification 01 natural sciences Genetic load 03 medical and health sciences 030104 developmental biology C400 Genetics education Domestication 010606 plant biology & botany |
| Popis: | Sorghum and maize share a close evolutionary history that can be explored through comparative genomics1,2. To perform a large-scale comparison of the genomic variation between these two species, we analysed ~13 million variants identified from whole-genome resequencing of 499 sorghum lines together with 25 million variants previously identified in 1,218 maize lines. Deleterious mutations in both species were prevalent in pericentromeric regions, enriched in non-syntenic genes and present at low allele frequencies. A comparison of deleterious burden between sorghum and maize revealed that sorghum, in contrast to maize, departed from the domestication-cost hypothesis that predicts a higher deleterious burden among domesticates compared with wild lines. Additionally, sorghum and maize population genetic summary statistics were used to predict a gene deleterious index with an accuracy greater than 0.5. This research represents a key step towards understanding the evolutionary dynamics of deleterious variants in sorghum and provides a comparative genomics framework to start prioritizing these variants for removal through genome editing and breeding. Comparative genomics revealed similar distribution patterns of deleterious mutations in maize and sorghum but a post-domestication reduction of genetic load in sorghum, which is probably caused by sorghum’s high selfing rate and unique domestication history. |
| Databáze: | OpenAIRE |
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