Efficacy of lycopene on modulation of renal antioxidant enzymes, ACE and ACE gene expression in hyperlipidaemic rats
| Autor: | Shafaq Noori, Tabassum Mahboob, Nazish Iqbal Khan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Medicine (General) Antioxidant Normal diet medicine.medical_treatment 030204 cardiovascular system & hematology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Lycopene R5-920 Internal medicine Gene expression Internal Medicine medicine 030212 general & internal medicine angiotensin converting enzyme chemistry.chemical_classification Creatinine biology business.industry hyperlipidaemia Angiotensin-converting enzyme Enzyme chemistry Catalase biology.protein Original Article business |
| Zdroj: | Journal of the Renin-Angiotensin-Aldosterone System, Vol 17 (2016) Journal of the Renin-Angiotensin-Aldosterone System: JRAAS |
| ISSN: | 1752-8976 |
| Popis: | Introduction: We aimed to evaluate the efficacy of lycopene on renal tissue antioxidant enzymes and angiotensin converting enzyme (ACE) gene expression and serum activity in diet-induced hyperlipidaemia. Methods: Thirty-two female Wistar albino rats (200–250 g weight), 5–6 months of age, were randomly selected and divided into four groups. Group I received normal diet; group II received 24 g high fat diet/100 g of daily diet; group III received 24 g high fat diet/100 g daily diet and 200 ml of lycopene extract (twice a week) for 8 weeks; and group IV received 200 ml oral lycopene extract twice a week for 8 weeks. Results: A marked increase was observed in plasma urea and creatinine levels, serum C-reactive protein, kidney weight, tissue renal malonyldialdehyde level, ACE gene expression and serum level, while a decrease catalase level among hyperlipidaemic rats was observed. Histologically, interstitial inflammation and proliferation was seen. Lycopene supplementation significantly decreased plasma urea and creatinine, serum ACE, renal tissue malonyldialdehyde level and C-reactive protein level, while it increased tissue antioxidant enzymes level and total protein. Tissue inflammation and proliferation was improved. Conclusions: This finding suggests that supplementation of lycopene is effective for renal antioxidant enzymes, ACE gene expression and ACE serum level in hyperlipidaemic rats. |
| Databáze: | OpenAIRE |
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