Association of IL-10 and TNF-α Polymorphisms with Dental Peri-Implant Disease Risk: A Meta-Analysis, Meta-Regression, and Trial Sequential Analysis
| Autor: | Santosh Kumar Tadakamadla, Parsia Choubsaz, Masoud Sadeghi, Ladan Jamshidy, Jyothi Tadakamadla |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Health Toxicology and Mutagenesis MEDLINE Cochrane Library Gastroenterology polymorphism 03 medical and health sciences 0302 clinical medicine peri-implant disease bone loss Polymorphism (computer science) Internal medicine medicine Genetic predisposition cytokine Meta-regression 030212 general & internal medicine Allele Risk factor business.industry Public Health Environmental and Occupational Health 030206 dentistry implant failure Meta-analysis Medicine business peri-implantitis |
| Zdroj: | International Journal of Environmental Research and Public Health, Vol 18, Iss 7697, p 7697 (2021) |
| ISSN: | 1661-7827 1660-4601 |
| Popis: | Genetic susceptibility has been reported to be an important risk factor for peri-implant disease (PID). The aim of this meta-analysis was to assess the association between TNF-α and IL-10 polymorphisms and PID susceptibility. The Web of Science, Cochrane Library, Scopus, and PubMed/Medline databases were searched for studies published until 12 April 2021. RevMan 5.3, CMA 2.0, SPSS 22.0, and trial sequential analysis software were used. Twelve studies were included in our analysis. The pooled ORs for the association of TNF-α (−308 G > A), IL-10 (−1082 A > G), IL-10 (−819 C > T), and IL-10 (−592 A > C) polymorphisms were 1.12, 0.93, 1.35, and 0.77 for allelic; 1.42, 0.95, 3.41, and 0.34 for homozygous; 1.19, 1.88, 1.23, and 0.49 for heterozygous, 1.53, 1.12, 1.41, and 0.39 for recessive; and 1.16, 1.87, 2.65, and 0.75 for dominant models, respectively, with all the estimates being insignificant. The results showed an association between TNF-α (−308 G > A) polymorphism and the risk of PID in patients of Asian ethnicity (OR = 1.59; p = 0.03). The present meta-analysis illustrated that TNF-α (−308 G > A), IL-10 (−1082 A > G), IL-10 (−819 C > T), and IL-10 (−592 A > C) polymorphisms were not associated with the risk of PID, whereas TNF-α (−308 G > A) polymorphism was associated with an elevated risk of PID in Asian patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|