Static cytometry identifies hyperdiploid childhood ALL
| Autor: | Szu-Hee Lee, Yan-Koon Kueh, Yili Zhang, Yueh-Chun Chen, Janette A van den Berghe |
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| Rok vydání: | 2000 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Bone Marrow Cells Biology hemic and lymphatic diseases Precursor cell Acute lymphocytic leukemia Genetics medicine Humans Molecular Biology Childhood all Retrospective Studies Infant Karyotype DNA Neoplasm Precursor Cell Lymphoblastic Leukemia-Lymphoma Aneuploidy Flow Cytometry medicine.disease Regimen medicine.anatomical_structure Child Preschool Karyotyping Immunology Bone marrow Ploidy Cytometry |
| Zdroj: | Cancer Genetics and Cytogenetics. 123:123-127 |
| ISSN: | 0165-4608 |
| Popis: | Hyperdiploid acute lymphoblastic leukemia of childhood has long been identified with a good prognosis. Identification of this subgroup before treatment commences would enable the most appropriate regimen to be selected. Static cytometry permits an assessment of the DNA content of morphologically selected interphase cells. The blast cells from seven retrospective and seven prospective cases were studied and the ploidy levels compared with the bone marrow karyotype. Static cytometry rapidly identified the hyperdiploid karyotype and, as it was performed specifically on blast cells, it also identified the percentage of these blast cells that were hyperdiploid. |
| Databáze: | OpenAIRE |
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