Effect of radiotherapy after breast-conserving surgery in older patients with early breast cancer and breast ductal carcinoma in situ: a meta-analysis
| Autor: | Xi Zhang, Jian Wu, Wen Jun Chen, Cong Cong Wu, You Chen, Shuang Shuang Sun, Xuan Zhang Huang, Chao Ying Zhang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Breast Neoplasms Mastectomy Segmental breast ductal carcinoma in situ 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine medicine Breast-conserving surgery older Humans 030212 general & internal medicine early breast cancer skin and connective tissue diseases radiotherapy Neoplasm Staging Postoperative Care business.industry Hazard ratio Absolute risk reduction medicine.disease Combined Modality Therapy Radiation therapy Survival Rate Carcinoma Intraductal Noninfiltrating Treatment Outcome 030220 oncology & carcinogenesis Meta-analysis Relative risk Number needed to treat Female Radiotherapy Adjuvant breast-conserving surgery Neoplasm Recurrence Local business Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Xuan-zhang Huang 1, * , You Chen 2, * , Wen-jun Chen 1 , Xi Zhang 1 , Cong-cong Wu 1 , Chao-ying Zhang 1 , Shuang-shuang Sun 1 , Jian Wu 1 1 Department of Chemotherapy and Radiotherapy, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou City 325027, P.R. China 2 The Wenzhou Dental Hospital, Wenzhou City 325027, P.R. China * These authors contributed equally to this work Correspondence to: Jian Wu, email: wzzjian1@163.com. Keywords: radiotherapy, breast-conserving surgery, older, early breast cancer, breast ductal carcinoma in situ Received: October 22, 2016 Accepted: February 28, 2017 Published: March 08, 2017 ABSTRACT Background: There are no consistent agreements on whether radiotherapy after breast-conserving surgery (BCS) could provide local control and survival benefit for older patients with early breast cancer or breast ductal carcinoma in situ (DCIS). The present study aimed to evaluate the efficacy of radiotherapy after BCS in older patients with early breast cancer or DCIS. Results: Radiotherapy could reduce the risk of local relapse in older patients with early breast cancer. The 5-year AR of local relapse was 2.2% and 6.2% for radiotherapy and non-radiotherapy group, respectively, with low 5-year ARD of 4.0% and high NNT of 25. The 10-year AR of local relapse was 5.3% and 10.5% for radiotherapy and non-radiotherapy group, respectively, with the 10-year ARD of 5.2% and NNT of 20. However, radiotherapy could not improve survival benefits, including overall survival, cancer-specific survival, breast-cancer-specific survival, and distant relapse. Moreover, radiotherapy could reduce the risk of ipsilateral breast events in older patients with DCIS. Materials and Methods: PubMed and Embase database were searched for relevant studies. Hazard ratios (HRs), risk ratios (RRs), absolute risk (AR), absolute risk difference (ARD), and number needed to treat (NNT) were used as effect measures to evaluate the efficacy of radiotherapy in older patients. Conclusions: Our study indicates that radiotherapy could slightly reduce the risk of local relapse in older patients with favorable early breast cancer. However, radiotherapy cannot translate into significant survival benefits. |
| Databáze: | OpenAIRE |
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