Sydnone-alkyne cycloaddition: applications in synthesis and bioconjugation
| Autor: | Elodie Decuypere, Frédéric Taran, Davide Audisio, Lucie Plougastel |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Chemical biology
Alkyne Nanotechnology 010402 general chemistry 01 natural sciences Sydnones Catalysis chemistry.chemical_compound Materials Chemistry chemistry.chemical_classification Flexibility (engineering) Bioconjugation Cycloaddition Reaction 010405 organic chemistry Metals and Alloys Mesoionic General Chemistry Cycloaddition 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry Alkynes Ceramics and Composites Organic synthesis Click Chemistry Sydnone |
| Zdroj: | Chemical communications (Cambridge, England). 53(84) |
| ISSN: | 1364-548X |
| Popis: | Sydnones are among the most popular mesoionic compounds studied so far for cycloaddition reactions. However, despite their good chemical stability and versatility, only a limited number of research groups have worked on their chemistry and use in organic synthesis. This feature article aims at providing an overview of the most recent developments in sydnone–alkyne cycloadditions, with particular attention on the strategies that allow us to achieving high regiocontrol and milder reaction conditions. The recent discovery that this dipole is able to undergo click and biorthogonal reactions with cycloalkynes may stimulate renewed interest from the scientific community. Given the high potential and flexibility of this family of mesoionics, we believe that major developments are to be expected both in terms of organic synthetic methodologies and biorthogonal chemistry applications in the field of chemical biology. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|