Emergence and Dissemination of Extended‐Spectrum β‐Lactamase–Producing Escherichia coli in the Community: Lessons from the Study of a Remote and Controlled Population
| Autor: | Cécile Angebault, François Rousset, H. Jacquier, Magaly Renard, Olivier Clermont, David Skurnik, Assiya El Mniai, Etienne Ruppé, Loïc Epelboin, Régis Marc Bettinger, Mathilde Lescat, Anaelle Da Costa, Claire Dupont, Erick Denamur, Paul-Louis Woerther, Antoine Andremont, Félix Djossou, Guillaume Arlet, Didier Guillemot |
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| Přispěvatelé: | Hôpital Bichat, Assistance Publique - Hôpitaux de Paris, Emergence de la résistance bactérienne in vivo (EA3964), Université Paris Diderot - Paris 7 (UPD7), Physiopathologie et Pharmacotoxicologie Placentaire Humaine (U1139), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Genomic Research Laboratory [Geneva, Switzerland], Geneva University Hospital (HUG), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Pharmacoépidémiologie et maladies infectieuses (PhEMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur [Paris]-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC), Ecologie et Evolution des Microorganismes (EEM), Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de médecine interne et maladies tropicales, CHU Bordeaux [Bordeaux]-Groupe hospitalier Saint-André, Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche pour le développement [IRD] : UR226, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Rural Population MESH: Escherichia coli/enzymology [SDV]Life Sciences [q-bio] Antibiotics Prevalence Drug resistance medicine.disease_cause Plasmid Risk Factors MESH: Community-Acquired Infections/microbiology Epidemiology polycyclic compounds Immunology and Allergy Escherichia coli Infections 0303 health sciences education.field_of_study Anti-Bacterial Agents French Guiana 3. Good health Community-Acquired Infections Infectious Diseases MESH: beta-Lactamases/biosynthesis MESH: Escherichia coli Infections/microbiology Carrier State Female Plasmids Adult medicine.medical_specialty medicine.drug_class Population MESH: Escherichia coli/isolation & purification [SDV.BC]Life Sciences [q-bio]/Cellular Biology Biology beta-Lactam Resistance beta-Lactamases Microbiology 03 medical and health sciences Escherichia coli medicine Humans education 030304 developmental biology 030306 microbiology Indians South American biochemical phenomena metabolism and nutrition bacterial infections and mycoses Drug Utilization MESH: beta-Lactam Resistance MESH: Carrier State/microbiology Carriage Genes Bacterial bacteria [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | Journal of Infectious Diseases Journal of Infectious Diseases, Oxford University Press (OUP), 2010, 202 (4), pp.515-523. ⟨10.1086/654883⟩ Journal of Infectious Diseases, 2010, 202 (4), pp.515-523. ⟨10.1086/654883⟩ |
| ISSN: | 0022-1899 1537-6613 |
| DOI: | 10.1086/654883⟩ |
| Popis: | Background Intestinal carriage is a key factor in extended-spectrum beta-lactamase (ESBL) infection epidemiology but is difficult to study in open communities. To overcome this problem, we studied a highly stable group of Amerindians for whom we reported an ESBL carriage prevalence of 3.2% in 2001. Methods In 2006, ESBL carriage was assessed among 163 healthy volunteer adults. ESBL isolates were identified, and their molecular resistance mechanisms were characterized. Antibiotic use in the year before sampling and the epidemiological characteristics of the population were analyzed. Results were compared to those obtained in 2001. Results In 2006, the ESBL carriage prevalence, exclusively comprising Escherichia coli, was 8.0%. It mainly consisted of CTX-M-type ESBL. The strains and plasmids carrying ESBL were heterogeneous, but 1 CTX-M-2-producing strain was found in 4.3% of the subjects analyzed. No individual risk factor was identified. However, overall antibiotic use had almost doubled since 2001. A 3-fold increase was noted for beta-lactams. Conclusions In this population, the frequency of ESBL increased with time because of the appearance of CTX-M ESBL, mimicking what occurs in the developed world. This resulted from the probable repeated introduction of new strains and plasmids and from interindividual dissemination. During the same period, antibiotic use substantially increased. |
| Databáze: | OpenAIRE |
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