The Vital Roles of Mesenchymal Stem Cells and the Derived Extracellular Vesicles in Promoting Angiogenesis After Acute Myocardial Infarction
Autor: | Yu-Yan Xiong, Yue-Jin Yang, Li-Li Zhang |
---|---|
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Coronary artery occlusion Angiogenesis Myocardial Infarction Biology Mesenchymal Stem Cell Transplantation Extracellular vesicles Extracellular Vesicles 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Animals Humans Myocytes Cardiac cardiovascular diseases Myocardial infarction Myocardium Mesenchymal stem cell Mesenchymal Stem Cells Cell Biology Hematology medicine.disease Disease Models Animal 030104 developmental biology Cardiology Myocardial necrosis 030217 neurology & neurosurgery Developmental Biology |
Zdroj: | Stem Cells and Development. 30:561-577 |
ISSN: | 1557-8534 1547-3287 |
Popis: | Acute myocardial infarction (AMI) is an event of ischemic myocardial necrosis caused by acute coronary artery occlusion, which ultimately leads to a large loss of cardiomyocytes. The prerequisite of salvaging ischemic myocardium and improving cardiac function of patients is to provide adequate blood perfusion in the infarcted area. Apart from reperfusion therapy, it is also urgent and imperative to promote angiogenesis. Recently, growing evidence based on promising preclinical data indicates that mesenchymal stem cells (MSCs) can provide therapeutic effects on AMI by promoting angiogenesis. Extracellular vesicles (EVs), membrane-encapsulated vesicles with complex cargoes, including proteins, nucleic acids, and lipids, can be derived from MSCs and represent part of their functions, so EVs also possess the ability to promote angiogenesis. However, poor control of the survival and localization of MSCs hindered clinical transformation and made scientists start looking for new approaches based on MSCs. Identifying the role of MSCs and their derived EVs in promoting angiogenesis can provide a theoretical basis for improved MSC-based methods, and ultimately promote the clinical treatment of AMI. This review highlights potential proangiogenic mechanisms of transplanted MSCs and the derived EVs after AMI and summarizes the latest literature concerning the novel methods based on MSCs to maximize the angiogenesis capability. |
Databáze: | OpenAIRE |
Externí odkaz: |