Associations among tooth loss, systemic inflammation and antibody titers to periodontal pathogens in Japanese patients with cardiovascular disease
| Autor: | Hiroki Sato, Yuka Shiheido, Norio Aoyama, Mitsuaki Isobe, Norihiko Ashigaki, Tomoya Hanatani, Yuichi Izumi, Masato Minabe, Asuka Yoshida, Naho Kobayashi, Jun-ichi Suzuki |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Dentistry Disease 030204 cardiovascular system & hematology Systemic inflammation Tooth Loss 03 medical and health sciences 0302 clinical medicine Japan stomatognathic system Diabetes mellitus medicine Tooth loss Humans Jaw Edentulous Medical history Porphyromonas gingivalis Aged Aged 80 and over Periodontitis biology business.industry Jaw Edentulous Partially Antibody titer 030206 dentistry medicine.disease biology.organism_classification Antibodies Bacterial stomatognathic diseases C-Reactive Protein Cardiovascular Diseases Immunoglobulin G Periodontics Female medicine.symptom business |
| Zdroj: | Journal of Periodontal Research. 53:117-122 |
| ISSN: | 1600-0765 0022-3484 |
| DOI: | 10.1111/jre.12494 |
| Popis: | Background and objective It is well known that there is a strong relationship between periodontitis and cardiovascular disease (CVD). Tooth loss reflects an end-stage condition of oral diseases, such as periodontitis. Infection with specific periodontal pathogens is known as a possible factor that influences development of CVD. The aim of this study was to assess the relationship between the number of residual teeth and systemic inflammatory conditions in patients with CVD. Material and methods We divided 364 patients with CVD into four groups, according to the number of residual teeth: (i) ≥20 teeth; (ii) 10-19 teeth; (iii) 1-9 teeth; and (iv) edentulous. We recorded medical history, blood data and periodontal conditions. Serum samples were obtained and their IgG titers against three major periodontal pathogens were measured. Results Smoking rate and the prevalence of diabetes mellitus were higher in edentulous patients and in subjects with a few teeth compared with patients with many teeth. The levels of C-reactive protein were higher in patients with 1-9 teeth than in those with 10-19 teeth and with ≥20 teeth. The level of Porphyromonas gingivalis IgG in the group with 10-19 teeth was statistically higher than that in the group with ≥20 teeth. The level of P. gingivalis IgG in the edentulous group tended to be lower than that in the other groups. Conclusion The patients with 1-9 teeth had the highest level of C-reactive protein among the four groups, and the patients with 10-19 teeth had the highest level of IgG to periodontal bacteria. We conclude that the number of remaining teeth may be used to estimate the severity of systemic inflammation in patients with CVD. |
| Databáze: | OpenAIRE |
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