Interspecies pharmacokinetic scaling of Sch 34343
| Autor: | Samson Symchowicz, E. M. Oden, Menger Chung, Chin-Chung Lin, Richard Gural, George H. Miller, Elaine Radwanski, David Loebenberg |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Male
Microbiology (medical) Investigational drug Lactams Pharmacology Body weight Mice Animal data Dogs Species Specificity Pharmacokinetics Animals Humans Distribution (pharmacology) Pharmacology (medical) Saimiri Chemistry Body Weight Half-life Total body Anti-Bacterial Agents Rats Kinetics Macaca fascicularis Infectious Diseases Injections Intravenous Rabbits Clearance |
| Zdroj: | Journal of Antimicrobial Chemotherapy. 15:227-233 |
| ISSN: | 1460-2091 0305-7453 |
| DOI: | 10.1093/jac/15.suppl_c.227 |
| Popis: | Pharmacokinetic parameters of Sch 34343 have been determined for mice, rats, rabbits, monkeys, dogs and humans and correlated among species as an exponential function of body weight. The pertinent pharmacokinetic parameters tested are apparent and steady-state volumes of distribution, total body clearance, elimination phase half-life, and mean residence time. This study showed that the extrapolation of animal data to humans on a new investigational drug, Sch 34343, can be potentially useful. |
| Databáze: | OpenAIRE |
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