Serum leptin levels in gastric cancer patients and the relationship with insulin resistance
| Autor: | Ahmet Cumhur Dülger, Mehmet Aslan, Habib Emre, Ramazan Esen, Huseyin Begenik, Ahu Sarbay Kemik, Ozgur Kemik |
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| Rok vydání: | 2015 |
| Předmět: |
insulin
medicine.medical_specialty medicine.medical_treatment Growth hormone leptin Insulin resistance Clinical Research insulin resistance Internal medicine gender medicine In patient Performance status business.industry gastric cancer Leptin Insulin digestive oral and skin physiology Cancer General Medicine medicine.disease Endocrinology growth hormone Serum leptin business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Archives of Medical Science : AMS |
| ISSN: | 1734-1922 |
| Popis: | Introduction Serum leptin levels have been examined in various cancers, with conflicting results. However, there is limited information regarding serum leptin levels and insulin resistance in gastric cancer patients. Therefore, we aimed to investigate serum leptin levels, performance status, insulin levels and insulin resistance in patients with gastric cancer. In addition, we examined the relationship between these measurements and leptin levels. Material and methods Thirty-nine patients with gastric cancer and 30 control subjects were enrolled in the study. Serum leptin, total protein, albumin, growth hormone, insulin and glucose levels were measured. The homeostasis model assessment (HOMA) was used to assess insulin resistance. Results Serum levels of insulin, glucose and growth hormone and insulin resistance were significantly lower in gastric cancer patients than controls (p < 0.05 for all). In the Pearson correlation analysis, insulin resistance was found to be significantly correlated with serum leptin levels in gastric cancer patients (r = 0.320, p = 0.047). We observed a significant negative correlation between performance status and insulin resistance in patients with cachexia (r = –0.512, p = 0.030), while no association was found in non-cachectic patients. Conclusions We concluded that serum leptin levels are significantly lower in gastric cancer patients. In addition, gastric cancer patients have decreases in insulin levels, insulin resistance and growth hormone levels. This study found a positive association between serum leptin levels and insulin resistance. Moreover, there is a negative association between serum leptin levels and growth hormone levels. Thus, low insulin and growth hormone levels may suppress the production of leptin in gastric cancer patients. |
| Databáze: | OpenAIRE |
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