Aetiology of acute meningoencephalitis in Cambodian children, 2010-2013
| Autor: | Menno D. de Jong, Paul F. Horwood, Bertrand Guillard, Xavier de Lamballerie, Denis R. St. Laurent, Jeremy Farrar, Veasna Duong, Beat Richner, Christopher Gorman, Alexandra Kerleguer, Channa Mey, Marc Eloit, Arnaud Tarantola, Ky Santy, Seiha Heng, Sopheak Hem, Justine Cheval, Heng Sothy, Bernadette Murgue, Philippe Dussart, Marc Lecuit, Philippe Buchy |
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| Přispěvatelé: | AII - Infectious diseases, Medical Microbiology and Infection Prevention, Unité de Virologie / Virology Unit [Phnom Penh], Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Kantha Bopha Hospitals Foundation, Réseau International des Instituts Pasteur (RIIP), PathoQuest, University of Amsterdam [Amsterdam] (UvA), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Biologie des Infections - Biology of Infection, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche pour le Développement (IRD), École des Hautes Études en Santé Publique [EHESP] (EHESP), Oxford University Clinical Research Unit [Ho Chi Minh City] (OUCRU), Unité d'Épidémiologie et de Santé Publique [Phnom Penh], GlaxoSmithKline, Glaxo Smith Kline, This study was supported by the Li Ka Shing Foundation-University of Oxford Global Health Programme 2007–2010, PathoQuest (convention 04-12), and the Institut Microbiology and Maladies Infectieuses (IMMI NO 201103)., Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Tarantola, Arnaud |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Orientia tsutsugamushi paediatric Epidemiology encephalitis viruses MESH: Molecular Diagnostic Techniques MESH: Chikungunya Fever MESH: Dengue Dengue virus medicine.disease_cause Antibodies Viral MESH: Dengue Virus Serology Dengue 0302 clinical medicine [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases MESH: Child Drug Discovery 030212 general & internal medicine Chikungunya Child MESH: Encephalitis Japanese Encephalitis Virus Japanese biology MESH: Infant Newborn Meningoencephalitis meningoencephalitis meningitis virus diseases General Medicine MESH: Infant 3. Good health Infectious Diseases MESH: Scrub Typhus Molecular Diagnostic Techniques Child Preschool Acute Disease [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases MESH: Acute Disease MESH: Orientia tsutsugamushi Female Original Article Cambodia Meningitis Encephalitis Adolescent 030231 tropical medicine Immunology Microbiology 03 medical and health sciences Virology medicine Humans MESH: Meningoencephalitis Encephalitis Japanese MESH: Adolescent chikungunya virus MESH: Encephalitis Virus Japanese MESH: Humans dengue virus scrub typhus business.industry MESH: Cambodia MESH: Child Preschool Infant Newborn Infant MESH: Chikungunya virus Japanese encephalitis medicine.disease biology.organism_classification MESH: Male Japanese encephalitis virus Chikungunya Fever Parasitology business MESH: Female MESH: Antibodies Viral |
| Zdroj: | Emerging microbes and infections, 6(5). Nature Publishing Group Emerging microbes & infections Emerging microbes & infections, Earliest : Springer-Nature ; Latest : Taylor & Francis, 2017, 6 (5), pp.e35. ⟨10.1038/emi.2017.15⟩ Emerging microbes & infections, 2017, 6 (5), pp.e35. ⟨10.1038/emi.2017.15⟩ Emerging Microbes & Infections |
| ISSN: | 2222-1751 |
| Popis: | International audience; Acute meningoencephalitis (AME) is associated with considerable morbidity and mortality in children in developing countries. Clinical specimens were collected from children presenting with AME at two Cambodian paediatric hospitals to determine the major aetiologies associated with AME in the country. Cerebrospinal fluid (CSF) and blood samples were screened by molecular and cell culture methods for a range of pathogens previously associated with AME in the region. CSF and serum (acute and convalescent) were screened for antibodies to arboviruses such as Japanese encephalitis virus (JEV), dengue virus (DENV), and chikungunya virus (CHIKV). From July 2010 through December 2013, 1160 children (one month to 15 years of age) presenting with AME to two major paediatric hospitals were enroled into the study. Pathogens associated with AME were identified using molecular diagnostics, cell culture and serology. According to a diagnostic algorithm, a confirmed or highly probable aetiologic agent was detected in 35.0% (n=406) of AME cases, with a further 9.2% (total: 44.2%, n=513) aetiologies defined as suspected. JEV (24.4%, n=283) was the most commonly identified pathogen followed by Orientia tsutsugamushi (4.7%, n=55), DENV (4.6%, n=53), enteroviruses (3.5%, n=41), CHIKV (2.0%, n=23) and Streptococcus pneumoniae (1.6%, n=19). The majority of aetiologies identified for paediatric AME in Cambodia were vaccine preventable and/or treatable with appropriate antimicrobials. |
| Databáze: | OpenAIRE |
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