Oral supplementation of 2'-fucosyllactose during lactation improves memory and learning in rats
| Autor: | Agnès Gruart, Maria Laura Ramirez, Alejandro Barranco, Rachael Buck, José M. Delgado-García, Ricardo Rueda, Elena Oliveros, Enrique Vazquez, Maria J Martin |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male Endocrinology Diabetes and Metabolism Clinical Biochemistry Long-Term Potentiation Morris water navigation task Physiology Administration Oral Biochemistry 03 medical and health sciences chemistry.chemical_compound 2'-Fucosyllactose In vivo Oral administration Pregnancy Lactation Medicine Weaning Animals Maze Learning Molecular Biology 030109 nutrition & dietetics Nutrition and Dietetics Behavior Animal business.industry Long-term potentiation Rats 030104 developmental biology medicine.anatomical_structure chemistry Infant formula Immunology Female business Trisaccharides |
| Zdroj: | The Journal of nutritional biochemistry. 31 |
| ISSN: | 1873-4847 |
| Popis: | Human milk oligosaccharides have been proposed to exert beneficial effects on brain development. During the last decades, most of the studies have focused on the evaluation of sialylated structures but recent experiments have also tested fucosylated oligosaccharides, i.e. 2′-fucosyllactose (2′-FL). The present study aimed to determine whether oral 2′-FL has an effect on the development of newborn brain, contributing to enhance cognitive skills later in life. Rat pups received an oral supplementation of 2′-FL (2′-FL group) or water (control group) during the lactation period. Thereafter, animals were maintained on a rodent standard diet. Rats ( n = 12 rats/group) were evaluated twice, at age 4–6 weeks and again at age 1 year, using classical behavioral tests. In vivo long-term potentiation (LTP) was also performed at the same ages ( n = 10 rats/group). Both groups showed similar behavior when the animals were assessed just after weaning (age 4–6 weeks), although the 2′-FL group seemed to perform slightly better in Morris Water Maze. At age 1 year, 2′-FL rats performed significantly better in the Novel Object Recognition and Y maze paradigms, when compared to controls. In addition, LTP was more intense and longer lasting in the rats supplemented with 2′-FL than in control animals, both in young and adult animals. Oral administration of 2′-FL exclusively during lactation enhanced cognitive abilities, not only in childhood but also in adulthood. |
| Databáze: | OpenAIRE |
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