A Killer Immunoglobulin - Like Receptor Gene - Content Haplotype and A Cognate Human Leukocyte Antigen Ligand are Associated with Autism
| Autor: | Randall Johnson, Jonna B. Westover, Michael Benson, Annelise Dykes, Anthony R. Torres |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Lymphokine-activated killer cell biology Autism Human leukocyte antigen (HLA) alleles Cell Human leukocyte antigen Natural killer T cell Molecular biology Article Natural killer cell 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure Transmission disequilibrium test (TDT) Immunology medicine biology.protein General Earth and Planetary Sciences KIR gene Antibody Receptor Gene Killer - cell immunoglobulin - like receptors (KIR) General Environmental Science |
| Zdroj: | Autism-open access |
| ISSN: | 2165-7890 |
| Popis: | The killing activity of natural killer cells is largely regulated by the binding of class I human leukocyte antigen cognate ligands to killer cell immunoglobulin - like receptor proteins. The killer cell immunoglobulin - like receptor gene - complex contains genes that activate and others that inhibit the killing state of natural killer cells depending on the binding of specific human leukocyte antigen cognate ligands. It has been suggested in previous publications that activating human leukocyte antigen / killer - cell immunoglobulin - like receptor complexes are increased in people with autism. We present data, which suggests that an activating cB01 / tA01 killer cell immunoglobulin - like receptor gene - content haplotype and the cognate ligand human leukocyte antigen - C1k that activates this haplotype is significantly increased in autism. This is an important observation suggesting that the interaction between two proteins encoded on different chromosomes increases natural killer cell killing in autism. |
| Databáze: | OpenAIRE |
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