The Anaerobic Regulatory Network Required for Pseudomonas aeruginosa Nitrate Respiration
| Autor: | Robert Krieger, Hiroyuki Arai, Max Schobert, Martin Eschbach, Beatrice Benkert, Kerstin Schreiber, Dieter Jahn |
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| Rok vydání: | 2007 |
| Předmět: |
Operon
Regulator Biology medicine.disease_cause Nitrate reductase Nitrate Reductase Microbiology chemistry.chemical_compound Nitrate Gene Order medicine Gene Regulation Anaerobiosis Nitrite Molecular Biology health care economics and organizations Regulator gene Nitrates Models Genetic Pseudomonas aeruginosa Gene Expression Regulation Bacterial Nitrite reductase Biochemistry chemistry Genes Bacterial Mutation |
| Zdroj: | Journal of Bacteriology. 189:4310-4314 |
| ISSN: | 1098-5530 0021-9193 |
| DOI: | 10.1128/jb.00240-07 |
| Popis: | In Pseudomonas aeruginosa , the narK 1 K 2 GHJI operon encodes two nitrate/nitrite transporters and the dissimilatory nitrate reductase. The narK 1 promoter is anaerobically induced in the presence of nitrate by the dual activity of the oxygen regulator Anr and the N-oxide regulator Dnr in cooperation with the nitrate-responsive two-component regulatory system NarXL. The DNA bending protein IHF is essential for this process. Similarly, narXL gene transcription is enhanced under anaerobic conditions by Anr and Dnr. Furthermore, Anr and NarXL induce expression of the N-oxide regulator gene dnr . Finally, NarXL in cooperation with Dnr is required for anaerobic nitrite reductase regulatory gene nirQ transcription. A cascade regulatory model for the fine-tuned genetic response of P. aeruginosa to anaerobic growth conditions in the presence of nitrate was deduced. |
| Databáze: | OpenAIRE |
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