Inability of Asian risk scoring systems to predict intravenous immunoglobulin resistance and coronary lesions in Kawasaki disease in an Italian cohort
| Autor: | Marianna Fabi, Paola Sogno Valin, Giorgia Di Fazzio, Francesca Lami, Lorenzo Iughetti, Cristina Cicero, Bertrand Tchana, Barbara Bigucci, Federico Marchetti, Enrico Valletta, Elena Corinaldesi, Laura Andreozzi, Marcello Lanari, Andrea Donti, Tetyana Bodnar, Chiara Landini, Monica Sprocati, Claudia Balsamo |
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| Přispěvatelé: | Fabi, Marianna, Andreozzi, Laura, Corinaldesi, Elena, Bodnar, Tetyana, Lami, Francesca, Cicero, Cristina, Tchana, Bertrand, Landini, Chiara, Sprocati, Monica, Bigucci, Barbara, Balsamo, Claudia, Sogno Valin, Paola, Di Fazzio, Giorgia, Iughetti, Lorenzo, Valletta, Enrico, Marchetti, Federico, Donti, Andrea, Lanari, Marcello |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Heart Diseases Risk-scoring system Drug Resistance Taiwan Mucocutaneous Lymph Node Syndrome Caucasian Risk Assessment Sensitivity and Specificity White People Decision Support Techniques 03 medical and health sciences 0302 clinical medicine Asian People Japan Risk Factors hemic and lymphatic diseases 030225 pediatrics Internal medicine Coronary artery lesion medicine Retrospective analysis IVIG resistance Humans Immunologic Factors Coronary artery lesions Kawasaki disease Risk-scoring systems Pediatrics Perinatology and Child Health 030212 general & internal medicine Child Retrospective Studies biology business.industry Immunoglobulins Intravenous Infant medicine.disease Predictive value Italy Child Preschool Cohort biology.protein Female Antibody business |
| Popis: | Since resistance to intravenous immunoglobulin (IVIG) is associated with coronary lesions (CALs) in Kawasaki disease (KD), it is crucial to identify patients at risk to protect them from coronary involvement. The available risk scores to predict IVIG resistance were developed in Asian populations in whom their effectiveness has been proven, but data on non-Asian children are limited. The aim of this study is to evaluate the ability of the Kobayashi, Egami, and Formosa risk scores to predict IVIG resistance and CALs in Italian patients with KD. A multicenter retrospective analysis involving children with KD diagnosed between 2000 and 2015 was carried out: 257 patients were enrolled (57.9% boys, 89.9% Caucasian); 43 patients were IVIG resistant (16.7%). The scores have low sensitivity and specificity in predicting IVIG resistance: respectively, KS 64% and 62.5%, ES 41.4% and 77.4%, and FS 70.8% and 44.9%. The predictive value of the 3 scores for predicting CALs was also poor.Conclusion: Kobayashi, Egami, and Formosa Scores are ineffective in predicting IVIG resistance and coronary involvement in a predominantly Caucasian cohort. A specific score system for mostly Caucasian children with KD is needed enable the early identification of those at risk for CALs who could benefit from intensified treatment. What is Known: • There are several risk scores developed in the Asian population to early identify patients with KD at risk for immunoglobulin-resistance and thus for coronary lesions. • Data are scarce on their effectiveness in non-Asian children. What is New: • We present a comprehensive analysis of the ability of 3 Asian risk scores in a cohort of mostly Caucasian children to predict immunoglobulin resistance and coronary involvement. • Low sensitivity and specificity of the Asian scores for immunoglobulin-resistance and coronary lesions suggest the need for criteria specific for different ethnicities. |
| Databáze: | OpenAIRE |
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