Self‐Identified African Americans and prostate cancer risk: West African genetic ancestry is associated with prostate cancer diagnosis and with higher Gleason sum on biopsy

Autor: Sandra M. Gaston, Kerry Dehimer, Jeffrey W. Nix, Mark S. DeGuenther, Peter N. Kolettis, Ebony Shah, Soroush Rais-Bahrami, Ravi Chinsky, William E. Grizzle, James E. Bryant, Norma Terrin, Hong Chang, Rick A. Kittles, George W. Adams, James Kearns
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Risk
Cancer Research
medicine.medical_specialty
Prostate biopsy
Genetic genealogy
Biopsy
Population
Black People
Disease
urologic and male genital diseases
lcsh:RC254-282
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
prostate biopsy
education
African American
Aged
Original Research
education.field_of_study
medicine.diagnostic_test
Genetic heterogeneity
business.industry
Cancer
Prostatic Neoplasms
Clinical Cancer Research
Middle Aged
medicine.disease
prostate cancer
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Black or African American
Africa
Western
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
West African ancestry
Neoplasm Grading
business
Zdroj: Cancer Medicine, Vol 8, Iss 16, Pp 6915-6922 (2019)
Cancer Medicine
ISSN: 2045-7634
Popis: Concerns about overtreatment of clinically indolent prostate cancer (PrCa) have led to recommendations that men who are diagnosed with low‐risk PrCa be managed by active surveillance (AS) rather than immediate definitive treatment. However the risk of underestimating the aggressiveness of a patient's PrCa can be a significant source of anxiety and a barrier to patient acceptance of AS. The uncertainty is particularly keen for African American (AA) men who are about 1.7 times more likely to be diagnosed with PrCa than European American (EA) men and about 2.4 times more likely to die of this disease. The AA population, as many other populations in the Americas, is genetically heterogeneous with varying degrees of admixture from West Africans (WAs), Europeans, and Native Americans (NAs). Recommendations for PrCa screening and management rarely consider potential differences in risk within the AA population. We compared WA genetic ancestry in AA men undergoing standard prostate biopsy who were diagnosed with no cancer, low‐grade PrCa (Gleason Sum 6), or higher grade PrCa (Gleason Sum 7‐10). We found that WA genetic ancestry was significantly higher in men who were diagnosed with PrCa on biopsy, compared to men who were cancer‐negative, and highest in men who were diagnosed with higher grade PrCa (Gleason Sum 7‐10). Incorporating WA ancestry into the guidelines for making decisions about when to obtain a biopsy and whether to choose AS may allow AA men to personalize their approach to PrCa screening and management.
African American men are at higher risk for prostate cancer but public health recommendations rarely consider potential differences in risk within the African American population. We found that in self‐identified African Americans, West African genetic ancestry was significantly higher in men who were diagnosed with PrCa on biopsy, compared to men who were cancer negative, and highest in men who were diagnosed with higher grade PrCa (Gleason Sum 7‐10). Incorporating West African ancestry into prostate cancer clinical guidelines may allow African American men to personalize their approach to screening and management.
Databáze: OpenAIRE
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