Botulinum toxin type A for the treatment and prevention of hypertrophic scars and keloids: Updated review
| Autor: | Lorna Martin Kasyanju Carrero, Wei-Wei Ma, Hou-Fang Liu, Bing-Rong Zhou, Xu-Feng Yin |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Cicatrix Hypertrophic Neurotoxins Gene Expression Dermatology 030230 surgery medicine.disease_cause law.invention 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Medicine Humans Botulinum Toxins Type A Review study Wound Healing business.industry Cell Cycle Fibroblasts Botulinum toxin Clinical trial Keloid Combined therapy Clostridium botulinum Hypertrophic scars business Botulinum toxin type medicine.drug |
| Zdroj: | Journal of cosmetic dermatology. 18(1) |
| ISSN: | 1473-2165 |
| Popis: | Botulinum Toxin Type A is a potent neurotoxin that is produced by a gram-positive bacteria clostridium botulinum. Its utilization in the treatment of various medical condition has expanded over the years in both medical and esthetic uses. It is being preferred by most physicians due to its efficacy and lack of side effects. It can be used as monotherapy or combined therapy. The aim of this review study was to show the role and mechanism of action of Botulinum toxin type A in the treatment and prevention of hypertrophic scars and keloids. The clear mechanisms underlying hypertrophic scars and keloids are still not clearly understood; however, the mechanism of action of Botulinum toxin type A has been shown to include action on wound tension, action on collagen, and action on fibroblasts. Different randomized controlled trials, double-blind, and placebo-controlled studies have been conducted to investigate its use in treatment and prevention of hypertrophic scars and keloids, and it still is one of the active areas of research in Dermatology and related fields. Method: In March 2018, we performed a literature search in PubMed for clinical studies, clinical trials, case reports, controlled trials, randomized controlled trials, and systemic reviews. The search terms we used were "BOTULINUM TOXIN" AND "HYPERTROPHIC SCARS" OR "KELOIDS" (from 1980). The search resulted in 1000 articles, out of these 35 articles met our inclusion exclusion criteria. Our inclusion criteria included relevant original articles relevant, critical systemic reviews, and crucial referenced articles, exclusion criteria included duplicates and articles not published in English language. We have reviewed these papers to show the role and mechanism of action of Botulinum toxin type A in the treatment and prevention of hypertrophic scars and keloids. |
| Databáze: | OpenAIRE |
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