Genomic epidemiology of SARS-CoV-2 transmission lineages in Ecuador
| Autor: | Denisse Portugal, Mónica Becerra-Wong, Marina Escalera-Zamudio, Andrés Carrazco-Montalvo, Paul Cardenas, Leandro Patiño, Manuel Gonzalez, Josefina Coloma, Sully Márquez, Orson Mestanza, Gabriel Trueba, Oliver G. Pybus, Arne Kühne, Alberto Orlando, John T. McCrone, Domenica de Mora, Gabriela Sevillano, Nuno R. Faria, Rubén Armas-Gonzalez, Maritza Olmedo, Juan Carlos Fernandez-Cadena, Bernardo Gutierrez, Veronica Barragan, Moritz U. G. Kraemer, Alfredo Bruno, Louis du Plessis, Darlan da Silva Candido, Belén Prado-Vivar, Gabriel Morey-León, Jan Felix Drexler, Derly Andrade-Molina, Juan José Guadalupe, Anna-Lena Sander, Andres Moreira-Soto, Patricio Rojas-Silva, Michelle Grunauer, Sebastian Brünink, Jeannete Zurita |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
media_common.quotation_subject Context (language use) phylogeography molecular epidemiology Microbiology Genome Article law.invention 03 medical and health sciences law Virology Epidemiology Pandemic medicine AcademicSubjects/MED00860 Molecular clock 030304 developmental biology media_common 0303 health sciences Genetic diversity Molecular epidemiology SARS-CoV-2 030306 microbiology AcademicSubjects/SCI01130 AcademicSubjects/SCI02285 phylogenetics Phylogeography Geography Transmission (mechanics) Evolutionary biology transmission lineages Research Article Diversity (politics) |
| Zdroj: | Virus Evolution, 7 (2) medRxiv article-version (status) pre article-version (number) 1 Virus Evolution |
| ISSN: | 2057-1577 |
| DOI: | 10.1101/2021.03.31.21254685 |
| Popis: | Characterisation of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic diversity through space and time can reveal trends in virus importation and domestic circulation and permit the exploration of questions regarding the early transmission dynamics. Here, we present a detailed description of SARS-CoV-2 genomic epidemiology in Ecuador, one of the hardest hit countries during the early stages of the coronavirus-19 pandemic. We generated and analysed 160 whole genome sequences sampled from all provinces of Ecuador in 2020. Molecular clock and phylogeographic analysis of these sequences in the context of global SARS-CoV-2 diversity enable us to identify and characterise individual transmission lineages within Ecuador, explore their spatiotemporal distributions, and consider their introduction and domestic circulation. Our results reveal a pattern of multiple international importations across the country, with apparent differences between key provinces. Transmission lineages were mostly introduced before the implementation of non-pharmaceutical interventions, with differential degrees of persistence and national dissemination. Virus Evolution, 7 (2) ISSN:2057-1577 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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