| Autor: |
Jean-Pierre J. Issa, Gabriel G. Malouf, Takahiro Sato, Hanghang Zhang, Saira Ahmed, Vazganush Gharibyan, Justin T. Lee, Elodie M. Da Costa, Noël J.-M. Raynal |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1535-7163.22503463.v1 |
| Popis: |
Supplementary Fig. S1: Percentage of drugs per drug class among drug libraries used in the HTS; Supplementary Fig. S2: Synergistic GFP reactivation in YB5 cells by HDACi TSA and positive hits identified in the HTS; Supplementary Fig. S3: Optimization of the treatment schedule of the decitabine and proscillaridin A combination; Supplementary Fig. S4: Transcriptome analysis using Metascape; Supplementary Table S1: List of GO-Terms identified by Metascape analysis in gene data sets exclusively up-regulated by proscillaridin A treatment and exclusively up-regulated by the combination treatment; Supplementary Table S2: List of GO-Terms identified by Metascape analysis among down-regulated genes shared by proscillaridin A and the combinatorial treatment with decitabine; Supplementary Table S3: Antagonistic hits identified in combination HTS with sequential decitabine treatment; Supplementary Table S4. Antagonistic hits identified in combination HTS with simultaneous decitabine treatment; Supplementary Table S5. Antagonistic hits identified in combination HTS with sequential TSA treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
