Emerging BRAF Mutations in Cancer Progression and Their Possible Effects on Transcriptional Networks
| Autor: | Christopher P. Wardell, Paweł Leszczyński, Hidetoshi Kono, Magdalena Śmiech, Hiroaki Taniguchi |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
MAPK/ERK pathway lcsh:QH426-470 Biology Gene mutation BRAF 03 medical and health sciences 0302 clinical medicine oncogene transcription factors Genetics medicine cancer MAPK/ERK Genetics (clinical) Regulation of gene expression Oncogene Kinase Melanoma medicine.disease mutations lcsh:Genetics 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Signal transduction V600E |
| Zdroj: | Genes, Vol 11, Iss 1342, p 1342 (2020) |
| ISSN: | 2073-4425 |
| Popis: | Gene mutations can induce cellular alteration and malignant transformation. Development of many types of cancer is associated with mutations in the B-raf proto-oncogene (BRAF) gene. The encoded protein is a component of the mitogen-activated protein kinases/extracellular signal-regulated kinases (MAPK/ERK) signaling pathway, transmitting information from the outside to the cell nucleus. The main function of the MAPK/ERK pathway is to regulate cell growth, migration, and proliferation. The most common mutations in the BRAF gene encode the V600E mutant (class I), which causes continuous activation and signal transduction, regardless of external stimulus. Consequently, cell proliferation and invasion are enhanced in cancer patients with such mutations. The V600E mutation has been linked to melanoma, colorectal cancer, multiple myeloma, and other types of cancers. Importantly, emerging evidence has recently indicated that new types of mutations (classes II and III) also play a paramount role in the development of cancer. In this minireview, we discuss the influence of various BRAF mutations in cancer, including aberrant transcriptional gene regulation in the affected tissues. |
| Databáze: | OpenAIRE |
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